Ankyrin repeat and SOCS box protein 6 (ASB-6)
1_MPFLH 6_ GFRRI 11_ IFEYQ 16_ PLVDA 21_ ILGSL 26_ GIQDP 31_ ERQES 36_ LDRPS 41_ YVASE 46_ ESRIL 51_ VLTEL 56_ LERKA 61_ HSPFY 66_ QEGVS 71_ NALLK 76_ MAELG 81_ LTRAA 86_ DVLLR 91_ HGANL 96_ NFEDP 101_ VTYYT 106_ ALHIA 111_ VLRNQ 116_ PDMVE 121_ LLVHH 126_ GADVN 131_ RRDRI 136_ HESSP 141_ LDLAS 146_ EEPER 151_ LPCLQ 156_ RLLDL 161_ GADVN 166_ AADKH 171_ GKTAL 176_ LHALA 181_ SSDGV 186_ QIHNT 191_ ENIRL 196_ LLEGG 201_ ADVKA 206_ TTKDG 211_ DTVFT 216_ CIIFL 221_ LGETV 226_ GGDKE 231_ EAQMI 236_ NRFCF 241_ QVTRL 246_ LLAHG 251_ ADPSE 256_ CPAHE 261_ SLTHI 266_ CLKSF 271_ KLHFP 276_ LLRFL 281_ LESGA 286_ AYNCS 291_ LHGAS 296_ CWSGF 301_ HIIFE 306_ RLCSH 311_ PGCTE 316_ DESHA 321_ DLLRK 326_ AETVL 331_ DLMVT 336_ NSQKL 341_ QLPEN 346_ FDIHP 351_ VGSLA 356_ EKIQA 361_ LHFSL 366_ RQLES 371_ YPPPL 376_ KHLCR 381_ VAIRL 386_ YLQPW 391_ PVDVK 396_ VKALP 401_ LPDRL 406_ KWYLL 411_ SEHSG 416_SVEDD
1: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. May play a role in the regulation of cell proliferation and autophagy by promoting the ubiquitination and degradation of SQSTM1 (PubMed:34164402)