Probable tRNA(His) guanylyltransferase (EC 2.7.7.79) (Induced in high glucose-1) (IHG-1) (Interphase cytoplasmic foci protein 45) (tRNA-histidine guanylyltransferase)
1_MWGAC 6_ KVKVH 11_ DSLAT 16_ ISITL 21_ RRYLR 26_ LGATM 31_ AKSKF 36_ EYVRD 41_ FEADD 46_ TCLAH 51_ CWVVV 56_ RLDGR 61_ NFHRF 66_ AEKHN 71_ FAKPN 76_ DSRAL 81_ QLMTK 86_ CAQTV 91_ MEELE 96_ DIVIA 101_ YGQSD 106_ EYSFV 111_ FKRKT 116_ NWFKR 121_ RASKF 126_ MTHVA 131_ SQFAS 136_ SYVFY 141_ WRDYF 146_ EDQPL 151_ LYPPG 156_ FDGRV 161_ VVYPS 166_ NQTLK 171_ DYLSW 176_ RQADC 181_ HINNL 186_ YNTVF 191_ WALIQ 196_ QSGLT 201_ PVQAQ 206_ GRLQG 211_ TLAAD 216_ KNEIL 221_ FSEFN 226_ INYNN 231_ ELPMY 236_ RKGTV 241_ LIWQK 246_ VDEVM 251_ TKEIK 256_ LPTEM 261_ EGKKM 266_ AVTRT 271_ RTKPV 276_ PLHCD 281_ IIGDA 286_ FWKEH 291_PEILD
1: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (Probable). Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion (PubMed:25008184, PubMed:27307223). By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress (PubMed:25008184, PubMed:27307223)