NACHT, LRR and PYD domains-containing protein 2 (Nucleotide-binding site protein 1) (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2)
1_MVSSA 6_ QMGFN 11_ LQALL 16_ EQLSQ 21_ DELSK 26_ FKYLI 31_ TTFSL 36_ AHELQ 41_ KIPHK 46_ EVDKA 51_ DGKQL 56_ VEILT 61_ THCDS 66_ YWVEM 71_ ASLQV 76_ FEKMH 81_ RMDLS 86_ ERAKD 91_ EVREA 96_ ALKSF 101_ NKRKP 106_ LSLGI 111_ TRKER 116_ PPLDV 121_ DEMLE 126_ RFKTE 131_ AQAFT 136_ ETKGN 141_ VICLG 146_ KEVFK 151_ GKKPD 156_ KDNRC 161_ RYILK 166_ TKFRE 171_ MWKSW 176_ PGDSK 181_ EVQVM 186_ AERYK 191_ MLIPF 196_ SNPRV 201_ LPGPF 206_ SYTVV 211_ LYGPA 216_ GLGKT 221_ TLAQK 226_ LMLDW 231_ AEDNL 236_ IHKFK 241_ YAFYL 246_ SCREL 251_ SRLGP 256_ CSFAE 261_ LVFRD 266_ WPELQ 271_ DDIPH 276_ ILAQA 281_ RKILF 286_ VIDGF 291_ DELGA 296_ APGAL 301_ IEDIC 306_ GDWEK 311_ KKPVP 316_ VLLGS 321_ LLNRV 326_ MLPKA 331_ ALLVT 336_ TRPRA 341_ LRDLR 346_ ILAEE 351_ PIYIR 356_ VEGFL 361_ EEDRR 366_ AYFLR 371_ HFGDE 376_ DQAMR 381_ AFELM 386_ RSNAA 391_ LFQLG 396_ SAPAV 401_ CWIVC 406_ TTLKL 411_ QMEKG 416_ EDPVP 421_ TCLTR 426_ TGLFL 431_ RFLCS 436_ RFPQG 441_ AQLRG 446_ ALRTL 451_ SLLAA 456_ QGLWA 461_ QTSVL 466_ HREDL 471_ ERLGV 476_ QESDL 481_ RLFLD 486_ GDILR 491_ QDRVS 496_ KGCYS 501_ FIHLS 506_ FQQFL 511_ TALFY 516_ TLEKE 521_ EEEDR 526_ DGHTW 531_ DIGDV 536_ QKLLS 541_ GVERL 546_ RNPDL 551_ IQAGY 556_ YSFGL 561_ ANEKR 566_ AKELE 571_ ATFGC 576_ RMSPD 581_ IKQEL 586_ LRCDI 591_ SCKGG 596_ HSTVT 601_ DLQEL 606_ LGCLY 611_ ESQEE 616_ ELVKE 621_ VMAQF 626_ KEISL 631_ HLNAV 636_ DVVPS 641_ SFCVK 646_ HCRNL 651_ QKMSL 656_ QVIKE 661_ NLPEN 666_ VTASE 671_ SDAEV 676_ ERSQD 681_ DQHML 686_ PFWTD 691_ LCSIF 696_ GSNKD 701_ LMGLA 706_ INDSF 711_ LSASL 716_ VRILC 721_ EQIAS 726_ DTCHL 731_ QRVVF 736_ KNISP 741_ ADAHR 746_ NLCLA 751_ LRGHK 756_ TVTYL 761_ TLQGN 766_ DQDDM 771_ FPALC 776_ EVLRH 781_ PECNL 786_ RYLGL 791_ VSCSA 796_ TTQQW 801_ ADLSL 806_ ALEVN 811_ QSLTC 816_ VNLSD 821_ NELLD 826_ EGAKL 831_ LYTTL 836_ RHPKC 841_ FLQRL 846_ SLENC 851_ HLTEA 856_ NCKDL 861_ AAVLV 866_ VSREL 871_ THLCL 876_ AKNPI 881_ GNTGV 886_ KFLCE 891_ GLRYP 896_ ECKLQ 901_ TLVLW 906_ NCDIT 911_ SDGCC 916_ DLTKL 921_ LQEKS 926_ SLLCL 931_ DLGLN 936_ HIGVK 941_ GMKFL 946_ CEALR 951_ KPLCN 956_ LRCLW 961_ LWGCS 966_ IPPFS 971_ CEDLC 976_ SALSC 981_ NQSLV 986_ TLDLG 991_ QNPLG 996_ SSGVK 1001_ MLFET 1006_ LTCSS 1011_ GTLRT 1016_ LRLKI 1021_ DDFND 1026_ ELNKL 1031_ LEEIE 1036_ EKNPQ 1041_ LIIDT 1046_ EKHHP 1051_ WAERP 1056_SSHDF
1: Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature pro-inflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of pro-inflammatory caspases