Uncharacterized protein C1orf109
1_MTQDR 6_ PLLAV 11_ QEALK 16_ KCFPV 21_ VEEQQ 26_ GLWQS 31_ ALRDC 36_ QPLLS 41_ SLSNL 46_ AEQLQ 51_ AAQNL 56_ RFEDV 61_ PALRA 66_ FPDLK 71_ ERLRR 76_ KQLVA 81_ GDIVL 86_ DKLGE 91_ RLAIL 96_ LKVRD 101_ MVSSH 106_ VERVF 111_ QIYEQ 116_ HADTV 121_ GIDAV 126_ LQPSA 131_ VSPSV 136_ ADMLE 141_ WLQDI 146_ ERHYR 151_ KSYLK 156_ RKYLL 161_ SSIQW 166_ GDLAN 171_ IQALP 176_ KAWDR 181_ ISKDE 186_ HQDLV 191_ QDILL 196_NVSFF
1: Part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity (PubMed:38554706). Involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024)