COMM domain-containing protein 8
1_MEPEE 6_ GTPLW 11_ RLQKL 16_ PAELG 21_ PQLLH 26_ KIIDG 31_ ICGRA 36_ YPVYQ 41_ DYHTV 46_ WESEE 51_ WMHVL 56_ EDIAK 61_ FFKAI 66_ VGKNL 71_ PDEEI 76_ FQQLN 81_ QLNSL 86_ HQETI 91_ MKCVK 96_ SRKDE 101_ IKQAL 106_ SREIV 111_ AISSA 116_ QLQDF 121_ DWQVK 126_ LALSS 131_ DKIAA 136_ LRMPL 141_ LSLHL 146_ DVKEN 151_ GEVKP 156_ YSIEM 161_ SREEL 166_ QNLIQ 171_ SLEAA 176_NKVVL
1: Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966)