Succinate dehydrogenase assembly factor 2, mitochondrial (SDH assembly factor 2) (SDHAF2)
1_MAVST 6_ VFSTS 11_ SLMLA 16_ LSRHS 21_ LLSPL 26_ LSVTS 31_ FRRFY 36_ RGDSP 41_ TDSQK 46_ DMIEI 51_ PLPPW 56_ QERTD 61_ ESIET 66_ KRARL 71_ LYESR 76_ KRGML 81_ ENCIL 86_ LSLFA 91_ KEHLQ 96_ HMTEK 101_ QLNLY 106_ DRLIN 111_ EPSND 116_ WDIYY 121_ WATEA 126_ KPAPE 131_ IFENE 136_ VMALL 141_ RDFAK 146_ NKNKE 151_ QRLRA 156_ PDLEY 161_LFEKP
1: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer