H/ACA ribonucleoprotein complex subunit 2 (Nucleolar protein family A member 2) (snoRNP protein NHP2)
1_MTKIK 6_ ADPDG 11_ PEAQA 16_ EACSG 21_ ERTYQ 26_ ELLVN 31_ QNPIA 36_ QPLAS 41_ RRLTR 46_ KLYKC 51_ IKKAV 56_ KQKQI 61_ RRGVK 66_ EVQKF 71_ VNKGE 76_ KGIMV 81_ LAGDT 86_ LPIEV 91_ YCHLP 96_ VMCED 101_ RNLPY 106_ VYIPS 111_ KTDLG 116_ AAAGS 121_ KRPTC 126_ VIMVK 131_ PHEEY 136_ QEAYD 141_ ECLEE 146_VQSLP
1: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme