E3 ubiquitin-protein ligase MARCHF5 (EC 2.3.2.27) (Membrane-associated RING finger protein 5) (Membrane-associated RING-CH protein V) (MARCH-V) (Mitochondrial ubiquitin ligase) (MITOL) (RING finger protein 153) (RING-type E3 ubiquitin transferase MARCHF5)
1_MPDQA 6_ LQQML 11_ DRSCW 16_ VCFAT 21_ DEDDR 26_ TAEWV 31_ RPCRC 36_ RGSTK 41_ WVHQA 46_ CLQRW 51_ VDEKQ 56_ RGNST 61_ ARVAC 66_ PQCNA 71_ EYLIV 76_ FPKLG 81_ PVVYV 86_ LDLAD 91_ RLISK 96_ ACPFA 101_ AAGIM 106_ VGSIY 111_ WTAVT 116_ YGAVT 121_ VMQVV 126_ GHKEG 131_ LDVME 136_ RADPL 141_ FLLIG 146_ LPTIP 151_ VMLIL 156_ GKMIR 161_ WEDYV 166_ LRLWR 171_ KYSNK 176_ LQILN 181_ SIFPG 186_ IGCPV 191_ PRIPA 196_ EANPL 201_ ADHVS 206_ ATRIL 211_ CGALV 216_ FPTIA 221_ TIVGK 226_ LMFSS 231_ VNSNL 236_ QRTIL 241_ GGIAF 246_ VAIKG 251_ AFKVY 256_ FKQQQ 261_ YLRQA 266_ HRKIL 271_NYPEQ
1: Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission and as an important regulator of immune response (PubMed:16874301, PubMed:17606867, PubMed:26246171, PubMed:31881323). Plays a crucial role in maintaining mitochondrial homeostasis by regulating the dynamics of mitochondria through the ubiquitination of key proteins involved in fission and fusion such as FIS1, DNM1L and MFN1 (PubMed:16874301, PubMed:17606867). Acts as a critical determinant of mitotic apoptosis through both MCL1-dependent and -independent pathways (By similarity). Turns off persistent immune signaling by degrading oligomeric complexes of retinoic acid-inducible gene I/DDX58 and mitochondrial antiviral-signaling protein/MAVS formed upon RNA virus infection (PubMed:26246171, PubMed:31881323). Promotes STING-mediated type-I interferon production via 'Lys-63'-linked ubiquitination of STING1 thereby preserving its activity and preventing the formation of inactive STING1 polymers (PubMed:37916870). Plays also an essential role in the formation of PEX3-containing vesicles in the de novo biogenesis of peroxisomes from mitochondria (PubMed:39423820, PubMed:39423819). Acts as a regulator of NLRP3 inflammasome activation on the mitochondria by mediating the 'Lys-27'-linked polyubiquitination of NLRP3, positively regulating the NLRP3-NEK7 complex formation and NLRP3 oligomerization (PubMed:37575012)