Ras-related protein Rab-20
1_MRKPD 6_ SKIVL 11_ LGDMN 16_ VGKTS 21_ LLQRY 26_ MERRF 31_ PDTVS 36_ TVGGA 41_ FYLKQ 46_ WRSYN 51_ ISIWD 56_ TAGRE 61_ QFHGL 66_ GSMYC 71_ RGAAA 76_ IILTY 81_ DVNHR 86_ QSLVE 91_ LEDRF 96_ LGLTD 101_ TASKD 106_ CLFAI 111_ VGNKV 116_ DLTEE 121_ GALAG 126_ QEKEE 131_ CSPNM 136_ DAGDR 141_ VSPRA 146_ PKQVQ 151_ LEDAV 156_ ALYKK 161_ ILKYK 166_ MLDEQ 171_ DVPAA 176_ EQMCF 181_ ETSAK 186_ TGYNV 191_ DLLFE 196_ TLFDL 201_ VVPMI 206_ LQQRA 211_ ERPSH 216_ TVDIS 221_ SHKPP 226_KRTRS
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB20 plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes