Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (Golgi-resident PAP phosphatase) (gPAPP) (EC 3.1.3.7) (3'(2'), 5'-bisphosphate nucleotidase 2) (Inositol monophosphatase domain-containing protein 1) (Myo-inositol monophosphatase A3) (Phosphoadenosine phosphate 3'-nucleotidase)
1_MAPMG 6_ IRLSP 11_ LGVAV 16_ FCLLG 21_ LGVLY 26_ HLYSG 31_ FLAGR 36_ FSLFG 41_ LGGEP 46_ GGGAA 51_ GPAAA 56_ ADGGT 61_ VDLRE 66_ MLAVS 71_ VLAAV 76_ RGGDE 81_ VRRVR 86_ ESNVL 91_ HEKSK 96_ GKTRE 101_ GAEDK 106_ MTSGD 111_ VLSNR 116_ KMFYL 121_ LKTAF 126_ PSVQI 131_ NTEEH 136_ VDAAD 141_ QEVIL 146_ WDHKI 151_ PEDIL 156_ KEVTT 161_ PKEVP 166_ AESVT 171_ VWIDP 176_ LDATQ 181_ EYTED 186_ LRKYV 191_ TTMVC 196_ VAVNG 201_ KPMLG 206_ VIHKP 211_ FSEYT 216_ AWAMV 221_ DGGSN 226_ VKARS 231_ SYNEK 236_ TPRIV 241_ VSRSH 246_ SGMVK 251_ QVALQ 256_ TFGNQ 261_ TTIIP 266_ AGGAG 271_ YKVLA 276_ LLDVP 281_ DKSQE 286_ KADLY 291_ IHVTY 296_ IKKWD 301_ ICAGN 306_ AILKA 311_ LGGHM 316_ TTLSG 321_ EEISY 326_ TGSDG 331_ IEGGL 336_ LASIR 341_ MNHQA 346_ LVRKL 351_PDLEK
1: Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4