MICOS complex subunit MIC19 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 3)
1_MGGTT 6_ STRRV 11_ TFEAD 16_ ENENI 21_ TVVKG 26_ IRLSE 31_ NVIDR 36_ MKESS 41_ PSGSK 46_ SQRYS 51_ GAYGA 56_ SVSDE 61_ ELKRR 66_ VAEEL 71_ ALEQA 76_ KKESE 81_ DQKRL 86_ KQAKE 91_ LDRER 96_ AAANE 101_ QLTRA 106_ ILRER 111_ ICSEE 116_ ERAKA 121_ KHLAR 126_ QLEEK 131_ DRVLK 136_ KQDAF 141_ YKEQL 146_ ARLEE 151_ RSSEF 156_ YRVTT 161_ EQYQK 166_ AAEEV 171_ EAKFK 176_ RYESH 181_ PVCAD 186_ LQAKI 191_ LQCYR 196_ ENTHQ 201_ TLKCS 206_ ALATQ 211_ YMHCV 216_ NHAKQ 221_SMLEK
1: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180, PubMed:32567732, PubMed:33130824). Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription (PubMed:22567091)