tRNA-dihydrouridine(20) synthase [NAD(P)+]-like (EC 1.3.1.91) (Dihydrouridine synthase 2) (Up-regulated in lung cancer protein 8) (URLC8) (tRNA-dihydrouridine synthase 2-like) (hDUS2)
1_MILNS 6_ LSLCY 11_ HNKLI 16_ LAPMV 21_ RVGTL 26_ PMRLL 31_ ALDYG 36_ ADIVY 41_ CEELI 46_ DLKMI 51_ QCKRV 56_ VNEVL 61_ STVDF 66_ VAPDD 71_ RVVFR 76_ TCERE 81_ QNRVV 86_ FQMGT 91_ SDAER 96_ ALAVA 101_ RLVEN 106_ DVAGI 111_ DVNMG 116_ CPKQY 121_ STKGG 126_ MGAAL 131_ LSDPD 136_ KIEKI 141_ LSTLV 146_ KGTRR 151_ PVTCK 156_ IRILP 161_ SLEDT 166_ LSLVK 171_ RIERT 176_ GIAAI 181_ AVHGR 186_ KREER 191_ PQHPV 196_ SCEVI 201_ KAIAD 206_ TLSIP 211_ VIANG 216_ GSHDH 221_ IQQYS 226_ DIEDF 231_ RQATA 236_ ASSVM 241_ VARAA 246_ MWNPS 251_ IFLKE 256_ GLRPL 261_ EEVMQ 266_ KYIRY 271_ AVQYD 276_ NHYTN 281_ TKYCL 286_ CQMLR 291_ EQLES 296_ PQGRL 301_ LHAAQ 306_ SSREI 311_ CEAFG 316_ LGAFY 321_ EETTQ 326_ ELDAQ 331_ QARLS 336_ AKTSE 341_ QTGEP 346_ AEDTS 351_ GVIKM 356_ AVKFD 361_ RRAYP 366_ AQITP 371_ KMCLL 376_ EWCRR 381_ EKLAQ 386_ PVYET 391_ VQRPL 396_ DRLFS 401_ SIVTV 406_ AEQKY 411_ QSTLW 416_ DKSKK 421_ LAEQA 426_ AAIVC 431_ LRSQG 436_ LPEGR 441_ LGEES 446_ PSLHK 451_ RKREA 456_ PDQDP 461_ GGPRA 466_ QELAQ 471_ PGDLC 476_ KKPFV 481_ ALGSG 486_EESPL
1: Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:15994936, PubMed:26429968, PubMed:30149704, PubMed:34798057, PubMed:38680565). Specifically modifies U20 in cytoplasmic tRNAs (PubMed:38680565). Activity depends on the presence of guanosine at position 19 in the tRNA substrate (PubMed:38680565). Negatively regulates the activation of EIF2AK2/PKR (PubMed:18096616)