CKLF-like MARVEL transmembrane domain-containing protein 6 (Chemokine-like factor superfamily member 6)
1_MENGA 6_ VYSPT 11_ TEEDP 16_ GPARG 21_ PRSGL 26_ AAYFF 31_ MGRLP 36_ LLRRV 41_ LKGLQ 46_ LLLSL 51_ LAFIC 56_ EEVVS 61_ QCTLC 66_ GGLYF 71_ FEFVS 76_ CSAFL 81_ LSLLI 86_ LIVYC 91_ TPFYE 96_ RVDTT 101_ KVKSS 106_ DFYIT 111_ LGTGC 116_ VFLLA 121_ SIIFV 126_ STHDR 131_ TSAEI 136_ AAIVF 141_ GFIAS 146_ FMFLL 151_ DFITM 156_ LYEKR 161_ QESQL 166_ RKPEN 171_ TTRAE 176_ALTEP
1: Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy