Endogenous retrovirus group K member 13-1 Env polyprotein (Envelope polyprotein) (HERV-K_16p13.3 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]
1_MWTVP 6_ SFTND 11_ SYQVY 16_ NVFST 21_ NSFQL 26_ LTVKR 31_ TPHEA 36_ WRVPL 41_ TTKTN 46_ KTKGL 51_ PDCPK 56_ KPTNG 61_ PFIVT 66_ SILWD 71_ NCNAP 76_ KAVVL 81_ QTLAM 86_ GIVID 91_ WAPKG 96_ HYWQD 101_ CSSKN 106_ TLCSE 111_ FIYSL 116_ DYIEH 121_ GWQSY 126_ TMRQR 131_ VSPYP 136_ FKWMD 141_ TGIAP 146_ PRPKI 151_ IHPFF 156_ TPEHP 161_ ELWKL 166_ AAALS 171_ GIKIW 176_ NTTYQ 181_ LLRTK 186_ TKTPT 191_ FNITL 196_ ISEWV 201_ IPIRS 206_ CVKPP 211_ YMLLV 216_ GNIIM 221_ MPDAQ 226_ TIECH 231_ NCKLF 236_ TCIDA 241_ TFNPT 246_ TSILL 251_ VRARE 256_ GVWIP 261_ VSLHR 266_ PWESS 271_ PSIHI 276_ VNEVL 281_ KDILK 286_ RTKRF 291_ IFTLI 296_ AVLAG 301_ LLAVT 306_ ATAAT 311_ AGVAI 316_ RSSVQ 321_ TAHYV 326_ EACQK 331_ NSSRL 336_ WNSQA 341_ QIDQK 346_ LANQI 351_ NDLRQ 356_ SVTWL 361_ GDRVM 366_ NLQHR 371_ MQLQC 376_ DWNTS 381_ DYCIT 386_ PYAYN 391_ QDQHS 396_ WENVS 401_ RHLKA 406_ WDDNL 411_ TLDIS 416_ QLKEQ 421_ IFEAS 426_ QAHLS 431_ TVPGS 436_ HIFEG 441_ ITKQL 446_ PDFNP 451_ FKWLK 456_ PVRGS 461_ LLLLA 466_ LLILV 471_ CLCCL 476_LLVCR
1: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution (By similarity)
2: SU mediates receptor recognition
3: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity)