NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 2.3.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5)
1_MRPLQ 6_ IVPSR 11_ LISQL 16_ YCGLK 21_ PPAST 26_ RNQIC 31_ LKMAR 36_ PSSSM 41_ ADFRK 46_ FFAKA 51_ KHIVI 56_ ISGAG 61_ VSAES 66_ GVPTF 71_ RGAGG 76_ YWRKW 81_ QAQDL 86_ ATPLA 91_ FAHNP 96_ SRVWE 101_ FYHYR 106_ REVMG 111_ SKEPN 116_ AGHRA 121_ IAECE 126_ TRLGK 131_ QGRRV 136_ VVITQ 141_ NIDEL 146_ HRKAG 151_ TKNLL 156_ EIHGS 161_ LFKTR 166_ CTSCG 171_ VVAEN 176_ YKSPI 181_ CPALS 186_ GKGAP 191_ EPGTQ 196_ DASIP 201_ VEKLP 206_ RCEEA 211_ GCGGL 216_ LRPHV 221_ VWFGE 226_ NLDPA 231_ ILEEV 236_ DRELA 241_ HCDLC 246_ LVVGT 251_ SSVVY 256_ PAAMF 261_ APQVA 266_ ARGVP 271_ VAEFN 276_ TETTP 281_ ATNRF 286_ RFHFQ 291_ GPCGT 296_ TLPEA 301_LACHE
1: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Activates SHMT2 by mediating its desuccinylation (PubMed:29180469). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX