Elongation of very long chain fatty acids protein 2 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL2) (ELOVL fatty acid elongase 2) (ELOVL FA elongase 2) (Very long chain 3-ketoacyl-CoA synthase 2) (Very long chain 3-oxoacyl-CoA synthase 2)
1_MEHLK 6_ AFDDE 11_ INAFL 16_ DNMFG 21_ PRDSR 26_ VRGWF 31_ MLDSY 36_ LPTFF 41_ LTVMY 46_ LLSIW 51_ LGNKY 56_ MKNRP 61_ ALSLR 66_ GILTL 71_ YNLGI 76_ TLLSA 81_ YMLAE 86_ LILST 91_ WEGGY 96_ NLQCQ 101_ DLTSA 106_ GEADI 111_ RVAKV 116_ LWWYY 121_ FSKSV 126_ EFLDT 131_ IFFVL 136_ RKKTS 141_ QITFL 146_ HVYHH 151_ ASMFN 156_ IWWCV 161_ LNWIP 166_ CGQSF 171_ FGPTL 176_ NSFIH 181_ ILMYS 186_ YYGLS 191_ VFPSM 196_ HKYLW 201_ WKKYL 206_ TQAQL 211_ VQFVL 216_ TITHT 221_ MSAVV 226_ KPCGF 231_ PFGCL 236_ IFQSS 241_ YMLTL 246_ VILFL 251_ NFYVQ 256_ TYRKK 261_ PMKKD 266_ MQEPP 271_ AGKEV 276_ KNGFS 281_ KAYFT 286_ AANGV 291_MNKKA
1: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators