GATOR complex protein MIOS (Missing oocyte meiosis regulator homolog)
1_MSGTK 6_ PDILW 11_ APHHV 16_ DRFVV 21_ CDSEL 26_ SLYHV 31_ ESTVN 36_ SELKA 41_ GSLRL 46_ SEDSA 51_ ATLLS 56_ INSDT 61_ PYMKC 66_ VAWYL 71_ NYDPE 76_ CLLAV 81_ GQANG 86_ RVVLT 91_ SLGQD 96_ HNSKF 101_ KDLIG 106_ KEFVP 111_ KHARQ 116_ CNTLA 121_ WNPLD 126_ SNWLA 131_ AGLDK 136_ HRADF 141_ SVLIW 146_ DICSK 151_ YTPDI 156_ VPMEK 161_ VKLSA 166_ GETET 171_ TLLVT 176_ KPLYE 181_ LGQND 186_ ACLSL 191_ CWLPR 196_ DQKLL 201_ LAGMH 206_ RNLAI 211_ FDLRN 216_ TSQKM 221_ FVNTK 226_ AVQGV 231_ TVDPY 236_ FHDRV 241_ ASFYE 246_ GQVAI 251_ WDLRK 256_ FEKPV 261_ LTLTE 266_ QPKPL 271_ TKVAW 276_ CPTRT 281_ GLLAT 286_ LTRDS 291_ NIIRL 296_ YDMQH 301_ TPTPI 306_ GDETE 311_ PTIIE 316_ RSVQP 321_ CDNYI 326_ ASFAW 331_ HPTSQ 336_ NRMIV 341_ VTPNR 346_ TMSDF 351_ TVFER 356_ ISLAW 361_ SPITS 366_ LMWAC 371_ GRHLY 376_ ECTEE 381_ ENDNS 386_ LEKDI 391_ ATKMR 396_ LRALS 401_ RYGLD 406_ TEQVW 411_ RNHIL 416_ AGNED 421_ PQLKS 426_ LWYTL 431_ HFMKQ 436_ YTEDM 441_ DQKSP 446_ GNKGS 451_ LVYAG 456_ IKSIV 461_ KSSLG 466_ MVESS 471_ RHNWS 476_ GLDKQ 481_ SDIQN 486_ LNEER 491_ ILALQ 496_ LCGWI 501_ KKGTD 506_ VDVGP 511_ FLNSL 516_ VQEGE 521_ WERAA 526_ AVALF 531_ NLDIR 536_ RAIQI 541_ LNEGA 546_ SSEKG 551_ DLNLN 556_ VVAMA 561_ LSGYT 566_ DEKNS 571_ LWREM 576_ CSTLR 581_ LQLNN 586_ PYLCV 591_ MFAFL 596_ TSETG 601_ SYDGV 606_ LYENK 611_ VAVRD 616_ RVAFA 621_ CKFLS 626_ DTQLN 631_ RYIEK 636_ LTNEM 641_ KEAGN 646_ LEGIL 651_ LTGLT 656_ KDGVD 661_ LMESY 666_ VDRTG 671_ DVQTA 676_ SYCML 681_ QGSPL 686_ DVLKD 691_ ERVQY 696_ WIENY 701_ RNLLD 706_ AWRFW 711_ HKRAE 716_ FDIHR 721_ SKLDP 726_ SSKPL 731_ AQVFV 736_ SCNFC 741_ GKSIS 746_ YSCSA 751_ VPHQG 756_ RGFSQ 761_ YGVSG 766_ SPTKS 771_ KVTSC 776_ PGCRK 781_ PLPRC 786_ ALCLI 791_ NMGTP 796_ VSSCP 801_ GGTKS 806_ DEKVD 811_ LSKDK 816_ KLAQF 821_ NNWFT 826_ WCHNC 831_ RHGGH 836_ AGHML 841_ SWFRD 846_ HAECP 851_ VSACT 856_ CKCMQ 861_ LDTTG 866_NLVPA
1: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:26586190, PubMed:27487210, PubMed:35831510, PubMed:36528027). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:26586190, PubMed:27487210, PubMed:35831510, PubMed:36528027). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25263562, PubMed:25457612, PubMed:26586190, PubMed:27487210). Within the GATOR2 complex, MIOS is required to prevent autoubiquitination of WDR24, the catalytic subunit of the complex (PubMed:35831510). The GATOR2 complex is required for brain myelination (By similarity)