Sphingomyelin phosphodiesterase 4 (EC 3.1.4.12) (Neutral sphingomyelinase 3) (nSMase-3) (nSMase3) (Neutral sphingomyelinase III)
1_MTTFG 6_ AVAEW 11_ RLPSL 16_ RRATL 21_ WIPQW 26_ FAKKA 31_ IFNSP 36_ LEAAM 41_ AFPHL 46_ QQPSF 51_ LLASL 56_ KADSI 61_ NKPFA 66_ QQCQD 71_ LVKVI 76_ EDFPA 81_ KELHT 86_ IFPWL 91_ VESIF 96_ GSLDG 101_ VLVGW 106_ NLRCL 111_ QGRVN 116_ PVEYS 121_ IVMEF 126_ LDPGG 131_ PMMKL 136_ VYKLQ 141_ AEDYK 146_ FDFPV 151_ SYLPG 156_ PVKAS 161_ IQECI 166_ LPDSP 171_ LYHNK 176_ VQFTP 181_ TGGLG 186_ LNLAL 191_ NPFEY 196_ YIFFF 201_ ALSLI 206_ TQKPL 211_ PVSLH 216_ VRTSD 221_ CAYFI 226_ LVDRY 231_ LSWFL 236_ PTEGS 241_ VPPPL 246_ SSSPG 251_ GTSPS 256_ PPPRT 261_ PAIPF 266_ ASYGL 271_ HHTSL 276_ LKRHI 281_ SHQTS 286_ VNADP 291_ ASHEI 296_ WRSET 301_ LLQVF 306_ VEMWL 311_ HHYSL 316_ EMYQK 321_ MQSPH 326_ AKLEV 331_ LHYRL 336_ SVSSA 341_ LYSPA 346_ QPSLQ 351_ ALHAY 356_ QESFT 361_ PTEEH 366_ VLVVR 371_ LLLKH 376_ LHAFA 381_ NSLKP 386_ EQASP 391_ SAHSH 396_ ATSPL 401_ EEFKR 406_ AAVPR 411_ FVQQK 416_ LYLFL 421_ QHCFG 426_ HWPLD 431_ ASFRA 436_ VLEMW 441_ LSYLQ 446_ PWRYA 451_ PDKQA 456_ PGSDS 461_ QPRCV 466_ SEKWA 471_ PFVQE 476_ NLLMY 481_ TKLFV 486_ GFLNR 491_ ALRTD 496_ LVSPK 501_ HALMV 506_ FRVAK 511_ VFAQP 516_ NLAEM 521_ IQKGE 526_ QLFLE 531_ PELVI 536_ PHRQH 541_ RLFTA 546_ PTFTG 551_ SFLSP 556_ WPPAV 561_ TDASF 566_ KVKSH 571_ VYSLE 576_ GQDCK 581_ YTPMF 586_ GPEAR 591_ TLVLR 596_ LAQLI 601_ TQAKH 606_ TAKSI 611_ SDQCA 616_ ESPAG 621_ HSFLS 626_ WLGFS 631_ SMDTN 636_ GSYTA 641_ NDLDE 646_ MGQDS 651_ VRKTD 656_ EYLEK 661_ ALEYL 666_ RQIFR 671_ LSEAQ 676_ LRQFT 681_ LALGT 686_ TQDEN 691_ GKKQL 696_ PDCIV 701_ GEDGL 706_ ILTPL 711_ GRYQI 716_ INGLR 721_ RFEIE 726_ YQGDP 731_ ELQPI 736_ RSYEI 741_ ASLVR 746_ TLFRL 751_ SSAIN 756_ HRFAG 761_ QMAAL 766_ CSRDD 771_ FLGSF 776_ CRYHL 781_ TEPGL 786_ ASRHL 791_ LSPVG 796_ RRQVA 801_ GHTRG 806_ PRLSL 811_ RFLGS 816_ YRTLV 821_ SLLLA 826_ FFVAS 831_ LFCVG 836_ PLPCT 841_ LLLTL 846_ GYVLY 851_ ASAMT 856_ LLTER 861_GKLHQ
1: Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (PubMed:16517606, PubMed:25180167). It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function (PubMed:31495489). May sensitize cells to DNA damage-induced apoptosis (PubMed:18505924). In skeletal muscle, mediates TNF-stimulated oxidant production (By similarity)