Palmitoyltransferase ZDHHC7 (EC 2.3.1.225) (Acyltransferase ZDHHC7) (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 7) (DHHC-7)
1_MQPSG 6_ HRLRD 11_ VEHHP 16_ LLAEN 21_ DNYDS 26_ SSSSS 31_ SEADV 36_ ADRVW 41_ FIRDG 46_ CGMIC 51_ AVMTW 56_ LLVAY 61_ ADFVV 66_ TFVML 71_ LPSKD 76_ FWYSV 81_ VNGVI 86_ FNCLA 91_ VLALS 96_ SHLRT 101_ MLTDP 106_ GAVPK 111_ GNATK 116_ EYMES 121_ LQLKP 126_ GEVIY 131_ KCPKC 136_ CCIKP 141_ ERAHH 146_ CSICK 151_ RCIRK 156_ MDHHC 161_ PWVNN 166_ CVGEK 171_ NQRFF 176_ VLFTM 181_ YIALS 186_ SVHAL 191_ ILCGF 196_ QFISC 201_ VRGQW 206_ TECSD 211_ FSPPI 216_ TVILL 221_ IFLCL 226_ EGLLF 231_ FTFTA 236_ VMFGT 241_ QIHSI 246_ CNDET 251_ EIERL 256_ KSEKP 261_ TWERR 266_ LRWEG 271_ MKSVF 276_ GGPPS 281_ LLWMN 286_ PFVGF 291_ RFRRL 296_ PTRPR 301_KGGPE
1: Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes (PubMed:22031296, PubMed:27380321, PubMed:28196865). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (PubMed:22031296). Palmitoylates GNAQ, a heterotrimeric G protein, regulating its dynamic localization at the plasma membrane and is thereby involved in GNAQ-dependent G protein-coupled receptor signaling pathways (PubMed:19001095). Also functions in ligand-induced cell death by regulating the FAS signaling pathway through the palmitoylation and stabilization of the receptor at the plasma membrane (PubMed:25301068). In epithelial cells, palmitoylates SCRIB and regulates its localization to the plasma membrane, regulating indirectly cell polarity and differentiation (PubMed:27380321). Also palmitoylates JAM3 and promotes its expression at tight junctions and regulates its function in cell migration (PubMed:28196865). Palmitoylates the glucose transporter GLUT4/SLC2A4 and controls the insulin-dependent translocation of GLUT4 to the plasma membrane (By similarity). In brain, could also palmitoylate SNAP25 and DLG4/PSD95 (By similarity). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Could also palmitoylate NCDN (By similarity). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity). Activates pyroptosis by catalyzing palmitoylation of gasdermin-D (GSDMD) (By similarity)