Transmembrane prolyl 4-hydroxylase (P4H-TM) (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 4) (HIF-PH4) (HIF-prolyl hydroxylase 4) (HPH-4)
1_MAAAA 6_ VTGQR 11_ PETAA 16_ AEEAS 21_ RPQWA 26_ PPDHC 31_ QAQAA 36_ AGLGD 41_ GEDAP 46_ VRPLC 51_ KPRGI 56_ CSRAY 61_ FLVLM 66_ VFVHL 71_ YLGNV 76_ LALLL 81_ FVHYS 86_ NGDES 91_ SDPGP 96_ QHRAQ 101_ GPGPE 106_ PTLGP 111_ LTRLE 116_ GIKVG 121_ HERKV 126_ QLVTD 131_ RDHFI 136_ RTLSL 141_ KPLLF 146_ EIPGF 151_ LTDEE 156_ CRLII 161_ HLAQM 166_ KGLQR 171_ SQILP 176_ TEEYE 181_ EAMST 186_ MQVSQ 191_ LDLFR 196_ LLDQN 201_ RDGHL 206_ QLREV 211_ LAQTR 216_ LGNGW 221_ WMTPE 226_ SIQEM 231_ YAAIK 236_ ADPDG 241_ DGVLS 246_ LQEFS 251_ NMDLR 256_ DFHKY 261_ MRSHK 266_ AESSE 271_ LVRNS 276_ HHTWL 281_ YQGEG 286_ AHHIM 291_ RAIRQ 296_ RVLRL 301_ TRLSP 306_ EIVEL 311_ SEPLQ 316_ VVRYG 321_ EGGHY 326_ HAHVD 331_ SGPVY 336_ PETIC 341_ SHTKL 346_ VANES 351_ VPFET 356_ SCRYM 361_ TVLFY 366_ LNNVT 371_ GGGET 376_ VFPVA 381_ DNRTY 386_ DEMSL 391_ IQDDV 396_ DLRDT 401_ RRHCD 406_ KGNLR 411_ VKPQQ 416_ GTAVF 421_ WYNYL 426_ PDGQG 431_ WVGDV 436_ DDYSL 441_ HGGCL 446_ VTRGT 451_ KWIAN 456_ NWINV 461_ DPSRA 466_ RQALF 471_ QQEMA 476_ RLARE 481_ GGTDS 486_ QPEWA 491_ LDRAY 496_RDARV
1: Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex