tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216) (tRNA 2,2-dimethylguanosine-26 methyltransferase) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase)
1_MQGSS 6_ LWLSL 11_ TFRSA 16_ RVLSR 21_ ARFFE 26_ WQSPG 31_ LPNTA 36_ AMENG 41_ TGPYG 46_ EERPR 51_ EVQET 56_ TVTEG 61_ AAKIA 66_ FPSAN 71_ EVFYN 76_ PVQEF 81_ NRDLT 86_ CAVIT 91_ EFARI 96_ QLGAK 101_ GIQIK 106_ VPGEK 111_ DTQKV 116_ VVDLS 121_ EQEEE 126_ KVELK 131_ ESENL 136_ ASGDQ 141_ PRTAA 146_ VGEIC 151_ EEGLH 156_ VLEGL 161_ AASGL 166_ RSIRF 171_ ALEVP 176_ GLRSV 181_ VANDA 186_ STRAV 191_ DLIRR 196_ NVQLN 201_ DVAHL 206_ VQPSQ 211_ ADARM 216_ LMYQH 221_ QRVSE 226_ RFDVI 231_ DLDPY 236_ GSPAT 241_ FLDAA 246_ VQAVS 251_ EGGLL 256_ CVTCT 261_ DMAVL 266_ AGNSG 271_ ETCYS 276_ KYGAM 281_ ALKSR 286_ ACHEM 291_ ALRIV 296_ LHSLD 301_ LRANC 306_ YQRFV 311_ VPLLS 316_ ISADF 321_ YVRVF 326_ VRVFT 331_ GQAKV 336_ KASAS 341_ KQALV 346_ FQCVG 351_ CGAFH 356_ LQRLG 361_ KASGV 366_ PSGRA 371_ KFSAA 376_ CGPPV 381_ TPECE 386_ HCGQR 391_ HQLGG 396_ PMWAE 401_ PIHDL 406_ DFVGR 411_ VLEAV 416_ SANPG 421_ RFHTS 426_ ERIRG 431_ VLSVI 436_ TEELP 441_ DVPLY 446_ YTLDQ 451_ LSSTI 456_ HCNTP 461_ SLLQL 466_ RSALL 471_ HADFR 476_ VSLSH 481_ ACKNA 486_ VKTDA 491_ PASAL 496_ WDIMR 501_ CWEKE 506_ CPVKR 511_ ERLSE 516_ TSPAF 521_ RILSV 526_ EPRLQ 531_ ANFTI 536_ REDAN 541_ PSSRQ 546_ RGLKR 551_ FQANP 556_ EANWG 561_ PRPRA 566_ RPGGK 571_ AADEA 576_ MEERR 581_ RLLQN 586_ KRKEP 591_ PEDVA 596_ QRAAR 601_ LKTFP 606_ CKRFK 611_ EGTCQ 616_ RGDQC 621_ CYSHS 626_ PPTPR 631_ VSADA 636_ APDCP 641_ ETSNQ 646_ TPPGP 651_GAAAG
1: Dimethylates a single guanine residue at position 26 of most nuclear- and mitochondrial-encoded tRNAs using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:10982862, PubMed:28784718, PubMed:37204604, PubMed:39786990). tRNA guanine(26)-dimethylation is required for redox homeostasis and ensure proper cellular proliferation and oxidative stress survival (PubMed:28784718)