E3 ubiquitin-protein ligase RNF186 (EC 2.3.2.27) (RING finger protein 186)
1_MACTK 6_ TLQQS 11_ QPISA 16_ GATTT 21_ TTAVA 26_ PAGGH 31_ SGSTE 36_ CDLEC 41_ LVCRE 46_ PYSCP 51_ RLPKL 56_ LACQH 61_ AFCAI 66_ CLKLL 71_ LCVQD 76_ NTWSI 81_ TCPLC 86_ RKVTA 91_ VPGGL 96_ ICSLR 101_ DHEAV 106_ VGQLA 111_ QPCTE 116_ VSLCP 121_ QGLVD 126_ PADLA 131_ AGHPS 136_ LVGED 141_ GQDEV 146_ SANHV 151_ AARRL 156_ AAHLL 161_ LLALL 166_ IILIG 171_ PFIYP 176_ GVLRW 181_ VLTFI 186_ IALAL 191_ LMSTL 196_ FCCLP 201_ STRGS 206_ CWPSS 211_ RTLFC 216_ REQKH 221_SHISS
1: E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress (PubMed:23896122). Stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis (PubMed:23896122). Plays a role in the maintenance of intestinal homeostasis and clearance of enteric pathogens. Upon NOD2 stimulation, ubiquitinates the ER stress sensor activating transcription factor 6/ATF6 and promotes the unfolded protein response UPR (PubMed:34623328). Participates in basal level of autophagy maintenance by regulating the ubiquitination of EPHB2 and EPHB3. Upon stimulation by ligand EFNB1, ubiquitinates EPHB2 and further recruits MAP1LC3B for autophagy induction (PubMed:33280498). Controls nutrient sensing by ubiquitinating Sestrin-2/SESN2, which is an intracellular sensor of cytosolic leucine and inhibitor of mTORC1 activity (PubMed:31586034)