F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) (F-box protein FBL12)
1_MATLV 6_ ELPDS 11_ VLLEI 16_ FSYLP 21_ VRDRI 26_ RISRV 31_ CHRWK 36_ RLVDD 41_ RWLWR 46_ HVDLT 51_ LYTMR 56_ PKVMW 61_ HLLRR 66_ YMASR 71_ LHSLR 76_ MGGYL 81_ FSGSQ 86_ APQLS 91_ PALLR 96_ ALGQK 101_ CPNLK 106_ RLCLH 111_ VADLS 116_ MVPIT 121_ SLPST 126_ LRTLE 131_ LHSCE 136_ ISMAW 141_ LHKQQ 146_ DPTVL 151_ PLLEC 156_ IVLDR 161_ VPAFR 166_ DEHLQ 171_ GLTRF 176_ RALRS 181_ LVLGG 186_ TYRVT 191_ ETGLD 196_ AGLQE 201_ LSYLQ 206_ RLEVL 211_ GCTLS 216_ ADSTL 221_ LAISR 226_ HLRDV 231_ RKIRL 236_ TVRGL 241_ SAPGL 246_ AVLEG 251_ MPALE 256_ SLCLQ 261_ GPLVT 266_ PEMPS 271_ PTEIL 276_ SSCLT 281_ MPKLR 286_ VLELQ 291_ GLGWE 296_ GQEAE 301_ KILCK 306_ GLPHC 311_ MVIVR 316_ ACPKE 321_SMDWW
1: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia