DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9)
1_MNSDQ 6_ VTLVG 11_ QVFES 16_ YVSEY 21_ HKNDI 26_ LLILK 31_ ERDED 36_ AHYPV 41_ VVNAM 46_ TLFET 51_ NMEIG 56_ EYFNM 61_ FPSEV 66_ LTIFD 71_ SALRR 76_ SALTI 81_ LQSLS 86_ QPEAV 91_ SMKQN 96_ LHARI 101_ SGLPV 106_ CPELV 111_ REHIP 116_ KTKDV 121_ GHFLS 126_ VTGTV 131_ IRTSL 136_ VKVLE 141_ FERDY 146_ MCNKC 151_ KHVFV 156_ IKADF 161_ EQYYT 166_ FCRPS 171_ SCPSL 176_ ESCDS 181_ SKFTC 186_ LSGLS 191_ SSPTR 196_ CRDYQ 201_ EIKIQ 206_ EQVQR 211_ LSVGS 216_ IPRSM 221_ KVILE 226_ DDLVD 231_ SCKSG 236_ DDLTI 241_ YGIVM 246_ QRWKP 251_ FQQDV 256_ RCEVE 261_ IVLKA 266_ NYIQV 271_ NNEQS 276_ SGIIM 281_ DEEVQ 286_ KEFED 291_ FWEYY 296_ KSDPF 301_ AGRNV 306_ ILASL 311_ CPQVF 316_ GMYLV 321_ KLAVA 326_ MVLAG 331_ GIQRT 336_ DATGT 341_ RVRGE 346_ SHLLL 351_ VGDPG 356_ TGKSQ 361_ FLKYA 366_ AKITP 371_ RSVLT 376_ TGIGS 381_ TSAGL 386_ TVTAV 391_ KDSGE 396_ WNLEA 401_ GALVL 406_ ADAGL 411_ CCIDE 416_ FNSLK 421_ EHDRT 426_ SIHEA 431_ MEQQT 436_ ISVAK 441_ AGLVC 446_ KLNTR 451_ TTILA 456_ ATNPK 461_ GQYDP 466_ QESVS 471_ VNIAL 476_ GSPLL 481_ SRFDL 486_ ILVLL 491_ DTKNE 496_ DWDRI 501_ ISSFI 506_ LENKG 511_ YPSKS 516_ EKLWS 521_ MEKMK 526_ TYFCL 531_ IRNLQ 536_ PTLSD 541_ VGNQV 546_ LLRYY 551_ QMQRQ 556_ SDCRN 561_ AARTT 566_ IRLLE 571_ SLIRL 576_ AEAHA 581_ RLMFR 586_ DTVTL 591_ EDAIT 596_ VVSVM 601_ ESSMQ 606_ GGALL 611_ GGVNA 616_ LHTSF 621_ PENPG 626_ EQYQR 631_ QCELI 636_ LEKLE 641_ LQSLL 646_ SEELR 651_ RLERL 656_ QNQSV 661_ HQSQP 666_ RVLEV 671_ ETTPG 676_ SLRNG 681_ PGEES 686_ NFRTS 691_ SQQEI 696_ NYSTH 701_ IFSPG 706_ GSPEG 711_ SPVLD 716_ PPPHL 721_ EPNRS 726_ TSRKH 731_ SAQHK 736_ NNRDD 741_ SLDWF 746_ DFMAT 751_ HQSEP 756_ KNTVV 761_ VSPHP 766_ KTSGE 771_ NMASK 776_ ISNST 781_ SQGKE 786_ KSEPG 791_ QRSKV 796_ DIGLL 801_ PSPGE 806_ TGVPW 811_ RADNV 816_ ESNKK 821_ KRLAL 826_ DSEAA 831_ VSADK 836_ PDSVL 841_ THHVP 846_ RNLQK 851_ LCKER 856_ AQKLC 861_ RNSTR 866_ VPAQC 871_ TVPSH 876_ PQSTP 881_ VHSPD 886_ RMLDS 891_ PKRKR 896_ PKSLA 901_ QVEEP 906_ AIENV 911_ KPPGS 916_ PVAKL 921_ AKFTF 926_ KQKSK 931_ LIHSF 936_ EDHSH 941_ VSPGA 946_ TKIAV 951_ HSPKI 956_ SQRRT 961_ RRDAA 966_ LPVKR 971_ PGKLT 976_ STPGN 981_ QISSQ 986_ PQGET 991_ KEVSQ 996_ QPPEK 1001_ HGPRE 1006_ KVMCA 1011_ PEKRI 1016_ IQPEL 1021_ ELGNE 1026_ TGCAH 1031_ LTCEG 1036_ DKKEE 1041_ VSGSN 1046_ KSGKV 1051_ HACTL 1056_ ARLAN 1061_ FCFTP 1066_ PSESK 1071_ SKSPP 1076_ PERKN 1081_ RGERG 1086_ PSSPP 1091_ TTTAP 1096_ MRVSK 1101_ RKSFQ 1106_ LRGST 1111_ EKLIV 1116_ SKESL 1121_ FTLPE 1126_ LGDEA 1131_ FDCDW 1136_DEEMR
1: Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MRN complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (PubMed:26300262). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). Probably by regulating HR, plays a key role during gametogenesis (By similarity)