Nuclear distribution protein nudE homolog 1 (NudE)
1_MEDSG 6_ KTFSS 11_ EEEEA 16_ NYWKD 21_ LAMTY 26_ KQRAE 31_ NTQEE 36_ LREFQ 41_ EGSRE 46_ YEAEL 51_ ETQLQ 56_ QIETR 61_ NRDLL 66_ SENNR 71_ LRMEL 76_ ETIKE 81_ KFEVQ 86_ HSEGY 91_ RQISA 96_ LEDDL 101_ AQTKA 106_ IKDQL 111_ QKYIR 116_ ELEQA 121_ NDDLE 126_ RAKRA 131_ TIMSL 136_ EDFEQ 141_ RLNQA 146_ IERNA 151_ FLESE 156_ LDEKE 161_ NLLES 166_ VQRLK 171_ DEARD 176_ LRQEL 181_ AVQQK 186_ QEKPR 191_ TPMPS 196_ SVEAE 201_ RTDTA 206_ VQATG 211_ SVPST 216_ PIAHR 221_ GPSSS 226_ LNTPG 231_ SFRRG 236_ LDDST 241_ GGTPL 246_ TPAAR 251_ ISALN 256_ IVGDL 261_ LRKVG 266_ ALESK 271_ LASCR 276_ NLVYD 281_ QSPNR 286_ TGGPA 291_ SGRSS 296_ KNRDG 301_ GERRP 306_ SSTSV 311_ PLGDK 316_ GLDTS 321_ CRWLS 326_KSTTR
1: Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a postmitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Acts as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (PubMed:34793709)