Inhibitor of growth protein 3 (p47ING3)
1_MLYLE 6_ DYLEM 11_ IEQLP 16_ MDLRD 21_ RFTEM 26_ REMDL 31_ QVQNA 36_ MDQLE 41_ QRVSE 46_ FFMNA 51_ KKNKP 56_ EWREE 61_ QMASI 66_ KKDYY 71_ KALED 76_ ADEKV 81_ QLANQ 86_ IYDLV 91_ DRHLR 96_ KLDQE 101_ LAKFK 106_ MELEA 111_ DNAGI 116_ TEILE 121_ RRSLE 126_ LDTPS 131_ QPVNN 136_ HHAHS 141_ HTPVE 146_ KRKYN 151_ PTSHH 156_ TTTDH 161_ IPEKK 166_ FKSEA 171_ LLSTL 176_ TSDAS 181_ KENTL 186_ GCRNN 191_ NSTAS 196_ SNNAY 201_ NVNSS 206_ QPLGS 211_ YNIGS 216_ LSSGT 221_ GAGAI 226_ TMAAA 231_ QAVQA 236_ TAQMK 241_ EGRRT 246_ SSLKA 251_ SYEAF 256_ KNNDF 261_ QLGKE 266_ FSMAR 271_ ETVGY 276_ SSSSA 281_ LMTTL 286_ TQNAS 291_ SSAAD 296_ SRSGR 301_ KSKNN 306_ NKSSS 311_ QQSSS 316_ SSSSS 321_ SLSSC 326_ SSSST 331_ VVQEI 336_ SQQTT 341_ VVPES 346_ DSNSQ 351_ VDWTY 356_ DPNEP 361_ RYCIC 366_ NQVSY 371_ GEMVG 376_ CDNQD 381_ CPIEW 386_ FHYGC 391_ VGLTE 396_ APKGK 401_ WYCPQ 406_ CTAAM 411_KRRGS
1: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome