Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (Alkylated DNA repair protein alkB homolog 4) (DNA N6-methyl adenine demethylase ALKBH4) (EC 1.14.11.51) (Lysine-specific demethylase ALKBH4) (EC 1.14.11.-)
1_MAAAA 6_ AETPE 11_ VLREC 16_ GCKGI 21_ RTCLI 26_ CERQR 31_ GSDPP 36_ WELPP 41_ AKTYR 46_ FIYCS 51_ DTGWA 56_ VGTEE 61_ SDFEG 66_ WAFPF 71_ PGVML 76_ IEDFV 81_ TREEE 86_ AELVR 91_ LMDRD 96_ PWKLS 101_ QSGRR 106_ KQDYG 111_ PKVNF 116_ RKQKL 121_ KTEGF 126_ CGLPS 131_ FSREV 136_ VRRMG 141_ LYPGL 146_ EGFRP 151_ VEQCN 156_ LDYCP 161_ ERGSA 166_ IDPHL 171_ DDAWL 176_ WGERL 181_ VSLNL 186_ LSPTV 191_ LSMCR 196_ EAPGS 201_ LLLCS 206_ APSAA 211_ PEALV 216_ DSVIA 221_ PSRSV 226_ LCQEV 231_ EVAIP 236_ LPARS 241_ LLVLT 246_ GAARH 251_ QWKHA 256_ IHRRH 261_ IEARR 266_ VCVTF 271_ RELSA 276_ EFGPG 281_ GRQQE 286_ LGQEL 291_ LRIAL 296_SFQGR
1: Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes (PubMed:23673617). Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (PubMed:23673617). In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing (By similarity)