Non-structural maintenance of chromosomes element 4 homolog A (NS4EA) (Non-SMC element 4 homolog A)
1_MSGDS 6_ SGRGP 11_ EGRGR 16_ GRDPH 21_ RDRTR 26_ SRSRS 31_ RSPLS 36_ PRSRR 41_ GSARE 46_ RREAP 51_ ERPSL 56_ EDTEP 61_ SDSGD 66_ EMMDP 71_ ASLEA 76_ EADQG 81_ LCRQI 86_ RHQYR 91_ ALINS 96_ VQQNR 101_ EDILN 106_ AGDKL 111_ TEVLE 116_ EANTL 121_ FNEVS 126_ RAREA 131_ VLDAH 136_ FLVLA 141_ SDLGK 146_ EKAKQ 151_ LRSDL 156_ SSFDM 161_ LRYVE 166_ TLLTH 171_ MGVNP 176_ LEAEE 181_ LIRDE 186_ DSPDF 191_ EFIVY 196_ DSWKI 201_ TGRTA 206_ ENTFN 211_ KTHTF 216_ HFLLG 221_ SIYGE 226_ CPVPK 231_ PRVDR 236_ PRKVP 241_ VIQEE 246_ RAMPA 251_ QLRRM 256_ EESHQ 261_ EATEK 266_ EVERI 271_ LGLLQ 276_ TYFRE 281_ DPDTP 286_ MSFFD 291_ FVVDP 296_ HSFPR 301_ TVENI 306_ FHVSF 311_ IIRDG 316_ FARIR 321_ LDQDR 326_ LPVIE 331_ PVSIN 336_ EENEG 341_ FEHNT 346_ QVRNQ 351_ GIIAL 356_ SYRDW 361_ EEIVK 366_ TFEIS 371_ EPVIT 376_PSQRQ
1: Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus