H/ACA ribonucleoprotein complex subunit 1 (Nucleolar protein family A member 1) (snoRNP protein GAR1)
1_MSFRG 6_ GGRGG 11_ FNRGG 16_ GGGGF 21_ NRGGS 26_ SNHFR 31_ GGGGG 36_ GGGGN 41_ FRGGG 46_ RGGFG 51_ RGGGR 56_ GGFNK 61_ GQDQG 66_ PPERV 71_ VLLGE 76_ FLHPC 81_ EDDIV 86_ CKCTT 91_ DENKV 96_ PYFNA 101_ PVYLE 106_ NKEQI 111_ GKVDE 116_ IFGQL 121_ RDFYF 126_ SVKLS 131_ ENMKA 136_ SSFKK 141_ LQKFY 146_ IDPYK 151_ LLPLQ 156_ RFLPR 161_ PPGEK 166_ GPPRG 171_ GGRGG 176_ RGGGR 181_ GGGGR 186_ GGGRG 191_ GGFRG 196_ GRGGG 201_ GGGFR 206_ GGRGG 211_GFRGR
1: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme