C-type lectin domain family 5 member A (C-type lectin superfamily member 5) (Myeloid DAP12-associating lectin 1) (MDL-1)
1_MNWHM 6_ IISGL 11_ IVVVL 16_ KVVGM 21_ TLFLL 26_ YFPQI 31_ FNKSN 36_ DGFTT 41_ TRSYG 46_ TVSQI 51_ FGSSS 56_ PSPNG 61_ FITTR 66_ SYGTV 71_ CPKDW 76_ EFYQA 81_ RCFFL 86_ STSES 91_ SWNES 96_ RDFCK 101_ GKGST 106_ LAIVN 111_ TPEKL 116_ KFLQD 121_ ITDAE 126_ KYFIG 131_ LIYHR 136_ EEKRW 141_ RWINN 146_ SVFNG 151_ NVTNQ 156_ NQNFN 161_ CATIG 166_ LTKTF 171_ DAASC 176_ DISYR 181_RICEK
1: Functions as a positive regulator of osteoclastogenesis (By similarity). Cell surface receptor that signals via TYROBP (PubMed:10449773). Regulates inflammatory responses (By similarity)
2: (Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4 (PubMed:18496526, PubMed:21566123). The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP (PubMed:18496526). This interaction does not result in viral entry, but stimulates pro-inflammatory cytokine release (PubMed:18496526)