Serine/threonine-protein phosphatase 4 regulatory subunit 2
1_MDVER 6_ LQEAL 11_ KDFEK 16_ RGKKE 21_ VCPVL 26_ DQFLC 31_ HVAKT 36_ GETMI 41_ QWSQF 46_ KGYFI 51_ FKLEK 56_ VMDDF 61_ RTSAP 66_ EPRGP 71_ PNPNV 76_ EYIPF 81_ DEMKE 86_ RILKI 91_ VTGFN 96_ GIPFT 101_ IQRLC 106_ ELLTD 111_ PRRNY 116_ TGTDK 121_ FLRGV 126_ EKNVM 131_ VVSCV 136_ YPSSE 141_ KNNSN 146_ SLNRM 151_ NGVMF 156_ PGNSP 161_ SYTER 166_ SNING 171_ PGTPR 176_ PLNRP 181_ KVSLS 186_ APMTT 191_ NGLPE 196_ STDSK 201_ EANLQ 206_ QNEEK 211_ NHSDS 216_ STSES 221_ EVSSV 226_ SPLKN 231_ KHPDE 236_ DAVEA 241_ EGHEV 246_ KRLRF 251_ DKEGE 256_ VRETA 261_ SQTTS 266_ SEISS 271_ VMVGE 276_ TEASS 281_ SSQDK 286_ DKDSR 291_ CTRQH 296_ CTEED 301_ EEEDE 306_ EEEEE 311_ SFMTS 316_ REMIP 321_ ERKNQ 326_ EKESD 331_ DALTV 336_ NEETS 341_ EENNQ 346_ MEESD 351_ VSQAE 356_ KDLLH 361_ SEGSE 366_ NEGPV 371_ SSSSS 376_ DCRET 381_ EELVG 386_ SNSSK 391_ TGEIL 396_ SESSM 401_ ENDDE 406_ ATEVT 411_DEPME
1: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair