Acid-sensing ion channel 5 (ASIC5) (Amiloride-sensitive cation channel 5) (Human intestine Na(+) channel) (HINaC)
1_MEQTE 6_ KSKVY 11_ AENGL 16_ LEKIK 21_ LCLSK 26_ KPLPS 31_ PTERK 36_ KFDHD 41_ FAIST 46_ SFHGI 51_ HNIVQ 56_ NRSKI 61_ RRVLW 66_ LVVVL 71_ GSVSL 76_ VTWQI 81_ YIRLL 86_ NYFTW 91_ PTTTS 96_ IEVQY 101_ VEKME 106_ FPAVT 111_ FCNLN 116_ RFQTD 121_ AVAKF 126_ GVIFF 131_ LWHIV 136_ SKVLH 141_ LQEIT 146_ ANSTG 151_ SREAT 156_ DFAAS 161_ HQNFS 166_ IVEFI 171_ RNKGF 176_ YLNNS 181_ TLLDC 186_ EFFGK 191_ PCSPK 196_ DFAHV 201_ FTEYG 206_ NCFTF 211_ NHGET 216_ LQAKR 221_ KVSVS 226_ GRGLS 231_ LLFNV 236_ NQEAF 241_ TDNPA 246_ LGFVD 251_ AGIIF 256_ VIHSP 261_ KKVPQ 266_ FDGLG 271_ LLSPV 276_ GMHAR 281_ VTIRQ 286_ VKTVH 291_ QEYPW 296_ GECNP 301_ NIKLQ 306_ NFSSY 311_ STSGC 316_ LKECK 321_ AQHIK 326_ KQCGC 331_ VPFLL 336_ PGYGI 341_ ECDLQ 346_ KYFSC 351_ VSPVL 356_ DHIEF 361_ KDLCT 366_ VGTHN 371_ SSCPV 376_ SCEEI 381_ EYPAT 386_ ISYSS 391_ FPSQK 396_ ALKYL 401_ SKKLN 406_ QSRKY 411_ IRENL 416_ VKIEI 421_ NYSDL 426_ NYKIT 431_ QQQKA 436_ VSVSE 441_ LLADL 446_ GGQLG 451_ LFCGA 456_ SLITI 461_ IEIIE 466_ YLFTN 471_ FYWIC 476_ IFFLL 481_ KISEM 486_ TQWTP 491_ PPQNH 496_LGNKN
1: Forms bile acid-gated sodium channels and may play a role in bile acid-dependent absorption and secretion by epithelial cells of the bile ducts (PubMed:10767424, PubMed:22735174). Displays high selectivity for sodium ions but can also permit the permeation of other cations (Probable). The gating could be indirect and the consequence of alterations of the membrane environment of the channel by bile acids (By similarity). As a sodium channel of type II unipolar brush cells of the vestibulocerebellum, controlling the electrical activity of these cells, could play a role in motor coordination and balance (By similarity)