Sodium channel protein type 3 subunit alpha (Sodium channel protein brain III subunit alpha) (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subtype III) (Voltage-gated sodium channel subunit alpha Nav1.3)
1_MAQAL 6_ LVPPG 11_ PESFR 16_ LFTRE 21_ SLAAI 26_ EKRAA 31_ EEKAK 36_ KPKKE 41_ QDNDD 46_ ENKPK 51_ PNSDL 56_ EAGKN 61_ LPFIY 66_ GDIPP 71_ EMVSE 76_ PLEDL 81_ DPYYI 86_ NKKTF 91_ IVMNK 96_ GKAIF 101_ RFSAT 106_ SALYI 111_ LTPLN 116_ PVRKI 121_ AIKIL 126_ VHSLF 131_ SMLIM 136_ CTILT 141_ NCVFM 146_ TLSNP 151_ PDWTK 156_ NVEYT 161_ FTGIY 166_ TFESL 171_ IKILA 176_ RGFCL 181_ EDFTF 186_ LRDPW 191_ NWLDF 196_ SVIVM 201_ AYVTE 206_ FVSLG 211_ NVSAL 216_ RTFRV 221_ LRALK 226_ TISVI 231_ PGLKT 236_ IVGAL 241_ IQSVK 246_ KLSDV 251_ MILTV 256_ FCLSV 261_ FALIG 266_ LQLFM 271_ GNLRN 276_ KCLQW 281_ PPSDS 286_ AFETN 291_ TTSYF 296_ NGTMD 301_ SNGTF 306_ VNVTM 311_ STFNW 316_ KDYIG 321_ DDSHF 326_ YVLDG 331_ QKDPL 336_ LCGNG 341_ SDAGQ 346_ CPEGY 351_ ICVKA 356_ GRNPN 361_ YGYTS 366_ FDTFS 371_ WAFLS 376_ LFRLM 381_ TQDYW 386_ ENLYQ 391_ LTLRA 396_ AGKTY 401_ MIFFV 406_ LVIFL 411_ GSFYL 416_ VNLIL 421_ AVVAM 426_ AYEEQ 431_ NQATL 436_ EEAEQ 441_ KEAEF 446_ QQMLE 451_ QLKKQ 456_ QEEAQ 461_ AVAAA 466_ SAASR 471_ DFSGI 476_ GGLGE 481_ LLESS 486_ SEASK 491_ LSSKS 496_ AKEWR 501_ NRRKK 506_ RRQRE 511_ HLEGN 516_ NKGER 521_ DSFPK 526_ SESED 531_ SVKRS 536_ SFLFS 541_ MDGNR 546_ LTSDK 551_ KFCSP 556_ HQSLL 561_ SIRGS 566_ LFSPR 571_ RNSKT 576_ SIFSF 581_ RGRAK 586_ DVGSE 591_ NDFAD 596_ DEHST 601_ FEDSE 606_ SRRDS 611_ LFVPH 616_ RHGER 621_ RNSNV 626_ SQASM 631_ SSRMV 636_ PGLPA 641_ NGKMH 646_ STVDC 651_ NGVVS 656_ LVGGP 661_ SALTS 666_ PTGQL 671_ PPEGT 676_ TTETE 681_ VRKRR 686_ LSSYQ 691_ ISMEM 696_ LEDSS 701_ GRQRA 706_ VSIAS 711_ ILTNT 716_ MEELE 721_ ESRQK 726_ CPPCW 731_ YRFAN 736_ VFLIW 741_ DCCDA 746_ WLKVK 751_ HLVNL 756_ IVMDP 761_ FVDLA 766_ ITICI 771_ VLNTL 776_ FMAME 781_ HYPMT 786_ EQFSS 791_ VLTVG 796_ NLVFT 801_ GIFTA 806_ EMVLK 811_ IIAMD 816_ PYYYF 821_ QEGWN 826_ IFDGI 831_ IVSLS 836_ LMELG 841_ LSNVE 846_ GLSVL 851_ RSFRL 856_ LRVFK 861_ LAKSW 866_ PTLNM 871_ LIKII 876_ GNSVG 881_ ALGNL 886_ TLVLA 891_ IIVFI 896_ FAVVG 901_ MQLFG 906_ KSYKE 911_ CVCKI 916_ NDDCT 921_ LPRWH 926_ MNDFF 931_ HSFLI 936_ VFRVL 941_ CGEWI 946_ ETMWD 951_ CMEVA 956_ GQTMC 961_ LIVFM 966_ LVMVI 971_ GNLVV 976_ LNLFL 981_ ALLLS 986_ SFSSD 991_ NLAAT 996_ DDDNE 1001_ MNNLQ 1006_ IAVGR 1011_ MQKGI 1016_ DYVKN 1021_ KMREC 1026_ FQKAF 1031_ FRKPK 1036_ VIEIH 1041_ EGNKI 1046_ DSCMS 1051_ NNTGI 1056_ EISKE 1061_ LNYLR 1066_ DGNGT 1071_ TSGVG 1076_ TGSSV 1081_ EKYVI 1086_ DENDY 1091_ MSFIN 1096_ NPSLT 1101_ VTVPI 1106_ AVGES 1111_ DFENL 1116_ NTEEF 1121_ SSESE 1126_ LEESK 1131_ EKLNA 1136_ TSSSE 1141_ GSTVD 1146_ VVLPR 1151_ EGEQA 1156_ ETEPE 1161_ EDLKP 1166_ EACFT 1171_ EGCIK 1176_ KFPFC 1181_ QVSTE 1186_ EGKGK 1191_ IWWNL 1196_ RKTCY 1201_ SIVEH 1206_ NWFET 1211_ FIVFM 1216_ ILLSS 1221_ GALAF 1226_ EDIYI 1231_ EQRKT 1236_ IKTML 1241_ EYADK 1246_ VFTYI 1251_ FILEM 1256_ LLKWV 1261_ AYGFQ 1266_ TYFTN 1271_ AWCWL 1276_ DFLIV 1281_ DVSLV 1286_ SLVAN 1291_ ALGYS 1296_ ELGAI 1301_ KSLRT 1306_ LRALR 1311_ PLRAL 1316_ SRFEG 1321_ MRVVV 1326_ NALVG 1331_ AIPSI 1336_ MNVLL 1341_ VCLIF 1346_ WLIFS 1351_ IMGVN 1356_ LFAGK 1361_ FYHCV 1366_ NMTTG 1371_ NMFDI 1376_ SDVNN 1381_ LSDCQ 1386_ ALGKQ 1391_ ARWKN 1396_ VKVNF 1401_ DNVGA 1406_ GYLAL 1411_ LQVAT 1416_ FKGWM 1421_ DIMYA 1426_ AVDSR 1431_ DVKLQ 1436_ PVYEE 1441_ NLYMY 1446_ LYFVI 1451_ FIIFG 1456_ SFFTL 1461_ NLFIG 1466_ VIIDN 1471_ FNQQK 1476_ KKFGG 1481_ QDIFM 1486_ TEEQK 1491_ KYYNA 1496_ MKKLG 1501_ SKKPQ 1506_ KPIPR 1511_ PANKF 1516_ QGMVF 1521_ DFVTR 1526_ QVFDI 1531_ SIMIL 1536_ ICLNM 1541_ VTMMV 1546_ ETDDQ 1551_ GKYMT 1556_ LVLSR 1561_ INLVF 1566_ IVLFT 1571_ GEFVL 1576_ KLVSL 1581_ RHYYF 1586_ TIGWN 1591_ IFDFV 1596_ VVILS 1601_ IVGMF 1606_ LAEMI 1611_ EKYFV 1616_ SPTLF 1621_ RVIRL 1626_ ARIGR 1631_ ILRLI 1636_ KGAKG 1641_ IRTLL 1646_ FALMM 1651_ SLPAL 1656_ FNIGL 1661_ LLFLV 1666_ MFIYA 1671_ IFGMS 1676_ NFAYV 1681_ KKEAG 1686_ IDDMF 1691_ NFETF 1696_ GNSMI 1701_ CLFQI 1706_ TTSAG 1711_ WDGLL 1716_ APILN 1721_ SAPPD 1726_ CDPDT 1731_ IHPGS 1736_ SVKGD 1741_ CGNPS 1746_ VGIFF 1751_ FVSYI 1756_ IISFL 1761_ VVVNM 1766_ YIAVI 1771_ LENFS 1776_ VATEE 1781_ SAEPL 1786_ SEDDF 1791_ EMFYE 1796_ VWEKF 1801_ DPDAT 1806_ QFIEF 1811_ SKLSD 1816_ FAAAL 1821_ DPPLL 1826_ IAKPN 1831_ KVQLI 1836_ AMDLP 1841_ MVSGD 1846_ RIHCL 1851_ DILFA 1856_ FTKRV 1861_ LGESG 1866_ EMDAL 1871_ RIQME 1876_ DRFMA 1881_ SNPSK 1886_ VSYEP 1891_ ITTTL 1896_ KRKQE 1901_ EVSAA 1906_ IIQRN 1911_ FRCYL 1916_ LKQRL 1921_ KNISS 1926_ NYNKE 1931_ AIKGR 1936_ IDLPI 1941_ KQDMI 1946_ IDKLN 1951_ GNSTP 1956_ EKTDG 1961_ SSSTT 1966_ SPPSY 1971_ DSVTK 1976_ PDKEK 1981_ FEKDK 1986_ PEKES 1991_KGKEV
1: Pore-forming subunit of Nav1.3, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:24157691, PubMed:28235671, PubMed:29466837, PubMed:35277491). In some secretory cell types, it also participates in cell excitability through membrane depolarization and regulates cells responsiveness to stimuli triggering secretion. For instance, it controls the release of serotonin/5-hydroxytryptamine by enterochromaffin cells and is required for both glucagon- and glucose-induced insulin secretion in pancreatic endocrine cells (By similarity)