Protein AATF (Apoptosis-antagonizing transcription factor) (Rb-binding protein Che-1)
1_MAGPQ 6_ PLALQ 11_ LEQLL 16_ NPRPS 21_ EADPE 26_ ADPEE 31_ ATAAR 36_ VIDRF 41_ DEGED 46_ GEGDF 51_ LVVGS 56_ IRKLA 61_ SASLL 66_ DTDKR 71_ YCGKT 76_ TSRKA 81_ WNEDH 86_ WEQTL 91_ PGSSD 96_ EEISD 101_ EEGSG 106_ DEDSE 111_ GLGLE 116_ EYDED 121_ DLGAA 126_ EEQEC 131_ GDHRE 136_ SKKSR 141_ SHSAK 146_ TPGFS 151_ VQSIS 156_ DFEKF 161_ TKGMD 166_ DLGSS 171_ EEEED 176_ EESGM 181_ EEGDD 186_ AEDSQ 191_ GESEE 196_ DRAGD 201_ RNSED 206_ DGVVM 211_ TFSSV 216_ KVSEE 221_ VEKGR 226_ AVKNQ 231_ IALWD 236_ QLLEG 241_ RIKLQ 246_ KALLT 251_ TNQLP 256_ QPDVF 261_ PLFKD 266_ KGGPE 271_ FSSAL 276_ KNSHK 281_ ALKAL 286_ LRSLV 291_ GLQEE 296_ LLFQY 301_ PDTRY 306_ LVDGT 311_ KPNAG 316_ SEEIS 321_ SEDDE 326_ LVEEK 331_ KQQRR 336_ RVPAK 341_ RKLEM 346_ EDYPS 351_ FMAKR 356_ FADFT 361_ VYRNR 366_ TLQKW 371_ HDKTK 376_ LASGK 381_ LGKGF 386_ GAFER 391_ SILTQ 396_ IDHIL 401_ MDKER 406_ LLRRT 411_ QTKRS 416_ VYRVL 421_ GKPEP 426_ AAQPV 431_ PESLP 436_ GEPEI 441_ LPQAP 446_ ANAHL 451_ KDLDE 456_ EIFDD 461_ DDFYH 466_ QLLRE 471_ LIERK 476_ TSSLD 481_ PNDQV 486_ AMGRQ 491_ WLAIQ 496_ KLRSK 501_ IHKKV 506_ DRKAS 511_ KGRKL 516_ RFHVL 521_ SKLLS 526_ FMAPI 531_ DHTTM 536_ NDDAR 541_ TELYR 546_ SLFGQ 551_LHPPD
1: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date