Sodium channel subunit beta-3
1_MPAFN 6_ RLFPL 11_ ASLVL 16_ IYWVS 21_ VCFPV 26_ CVEVP 31_ SETEA 36_ VQGNP 41_ MKLRC 46_ ISCMK 51_ REEVE 56_ ATTVV 61_ EWFYR 66_ PEGGK 71_ DFLIY 76_ EYRNG 81_ HQEVE 86_ SPFQG 91_ RLQWN 96_ GSKDL 101_ QDVSI 106_ TVLNV 111_ TLNDS 116_ GLYTC 121_ NVSRE 126_ FEFEA 131_ HRPFV 136_ KTTRL 141_ IPLRV 146_ TEEAG 151_ EDFTS 156_ VVSEI 161_ MMYIL 166_ LVFLT 171_ LWLLI 176_ EMIYC 181_ YRKVS 186_ KAEEA 191_ AQENA 196_ SDYLA 201_ IPSEN 206_KENSA
1: Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed:20558140, PubMed:21051419). Modulates the activity of SCN2A/Nav1.2, causing a hyperpolarizing shift in the voltage-dependence of inactivation of the channel and increasing the fraction of channels operating in the fast gating mode (By similarity). Modulates the activity of SCN5A/Nav1.5 (PubMed:20558140, PubMed:21051419, PubMed:24567321, PubMed:31950564). Could also regulate the atypical sodium channel SCN7A/Nav2.1 (PubMed:35301303). Modulates the activity of SCN10A/Nav1.8, regulating its oligomerization and accelerating the recovery from inactivation (PubMed:14975698)