Probable ATP-dependent RNA helicase DDX56 (EC 3.6.4.13) (ATP-dependent 61 kDa nucleolar RNA helicase) (DEAD box protein 21) (DEAD box protein 56)
1_MEDSE 6_ ALGFE 11_ HMGLD 16_ PRLLQ 21_ AVTDL 26_ GWSRP 31_ TLIQE 36_ KAIPL 41_ ALEGK 46_ DLLAR 51_ ARTGS 56_ GKTAA 61_ YAIPM 66_ LQLLL 71_ HRKAT 76_ GPVVE 81_ QAVRG 86_ LVLVP 91_ TKELA 96_ RQAQS 101_ MIQQL 106_ ATYCA 111_ RDVRV 116_ ANVSA 121_ AEDSV 126_ SQRAV 131_ LMEKP 136_ DVVVG 141_ TPSRI 146_ LSHLQ 151_ QDSLK 156_ LRDSL 161_ ELLVV 166_ DEADL 171_ LFSFG 176_ FEEEL 181_ KSLLC 186_ HLPRI 191_ YQAFL 196_ MSATF 201_ NEDVQ 206_ ALKEL 211_ ILHNP 216_ VTLKL 221_ QESQL 226_ PGPDQ 231_ LQQFQ 236_ VVCET 241_ EEDKF 246_ LLLYA 251_ LLKLS 256_ LIRGK 261_ SLLFV 266_ NTLER 271_ SYRLR 276_ LFLEQ 281_ FSIPT 286_ CVLNG 291_ ELPLR 296_ SRCHI 301_ ISQFN 306_ QGFYD 311_ CVIAT 316_ DAEVL 321_ GAPVK 326_ GKRRG 331_ RGPKG 336_ DKASD 341_ PEAGV 346_ ARGID 351_ FHHVS 356_ AVLNF 361_ DLPPT 366_ PEAYI 371_ HRAGR 376_ TARAN 381_ NPGIV 386_ LTFVL 391_ PTEQF 396_ HLGKI 401_ EELLS 406_ GENRG 411_ PILLP 416_ YQFRM 421_ EEIEG 426_ FRYRC 431_ RDAMR 436_ SVTKQ 441_ AIREA 446_ RLKEI 451_ KEELL 456_ HSEKL 461_ KTYFE 466_ DNPRD 471_ LQLLR 476_ HDLPL 481_ HPAVV 486_ KPHLG 491_ HVPDY 496_ LVPPA 501_ LRGLV 506_ RPHKK 511_ RKKLS 516_ SSCRK 521_ AKRAK 526_ SQNPL 531_ RSFKH 536_ KGKKF 541_RPTAK
1: Nucleolar RNA helicase that plays a role in various biological processes including innate immunity, ribosome biogenesis or nucleolus organization (PubMed:31340999, PubMed:33789112). Plays an essential role in maintaining nucleolar integrity in planarian stem cells (PubMed:33789112). Maintains embryonic stem cells proliferation by conventional regulation of ribosome assembly and interaction with OCT4 and POU5F1 complex (By similarity). Regulates antiviral innate immunity by inhibiting the virus-triggered signaling nuclear translocation of IRF3 (PubMed:31340999). Mechanistically, acts by disrupting the interaction between IRF3 and importin IPO5 (PubMed:31340999). May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity
2: (Microbial infection) Helicase activity is important for packaging viral RNA into virions during West Nile virus infection
3: (Microbial infection) Plays a positive role in foot-and-mouth disease virus replication by inhibiting the phosphorylation of IRF3 leading to inhibition of type I interferon
4: (Microbial infection) Plays a positive role in EMCV replication by interrupting IRF3 phosphorylation and its nucleus translocation