Myotubularin-related protein 4 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 2) (FYVE-DSP2) (Zinc finger FYVE domain-containing protein 11)
1_MGEEG 6_ PPSLE 11_ YIQAK 16_ DLFPP 21_ KELVK 26_ EEENL 31_ QVPFT 36_ VLQGE 41_ GVEFL 46_ GRAAD 51_ ALIAI 56_ SNYRL 61_ HIKFK 66_ DSVIN 71_ VPLRM 76_ IDSVE 81_ SRDMF 86_ QLHIS 91_ CKDSK 96_ VVRCH 101_ FSTFK 106_ QCQEW 111_ LSRLS 116_ RATAR 121_ PAKPE 126_ DLFAF 131_ AYHAW 136_ CLGLT 141_ EEDQH 146_ THLCQ 151_ PGEHI 156_ RCRQE 161_ AELAR 166_ MGFDL 171_ QNVWR 176_ VSHIN 181_ SNYKL 186_ CPSYP 191_ QKLLV 196_ PVWIT 201_ DKELE 206_ NVASF 211_ RSWKR 216_ IPVVV 221_ YRHLR 226_ NGAAI 231_ ARCSQ 236_ PEISW 241_ WGWRN 246_ ADDEY 251_ LVTSI 256_ AKACA 261_ LDPGT 266_ RATGG 271_ SLSTG 276_ NNDTS 281_ EACDA 286_ DFDSS 291_ LTACS 296_ GVEST 301_ AAPQK 306_ LLILD 311_ ARSYT 316_ AAVAN 321_ RAKGG 326_ GCECE 331_ EYYPN 336_ CEVVF 341_ MGMAN 346_ IHAIR 351_ NSFQY 356_ LRAVC 361_ SQMPD 366_ PSNWL 371_ SALES 376_ TKWLQ 381_ HLSVM 386_ LKAAV 391_ LVANT 396_ VDREG 401_ RPVLV 406_ HCSDG 411_ WDRTP 416_ QIVAL 421_ AKILL 426_ DPYYR 431_ TLEGF 436_ QVLVE 441_ SDWLD 446_ FGHKF 451_ GDRCG 456_ HQENV 461_ EDQNE 466_ QCPVF 471_ LQWLD 476_ SVHQL 481_ LKQFP 486_ CLFEF 491_ NEAFL 496_ VKLVQ 501_ HTYSC 506_ LYGTF 511_ LANNP 516_ CEREK 521_ RNIYK 526_ RTCSV 531_ WALLR 536_ AGNKN 541_ FHNFL 546_ YTPSS 551_ DMVLH 556_ PVCHV 561_ RALHL 566_ WTAVY 571_ LPASS 576_ PCTLG 581_ EENMD 586_ LYLSP 591_ VAQSQ 596_ EFSGR 601_ SLDRL 606_ PKTRS 611_ MDDLL 616_ SACDT 621_ SSPLT 626_ RTSSD 631_ PNLNN 636_ HCQEV 641_ RVGLE 646_ PWHSN 651_ PEGSE 656_ TSFVD 661_ SGVGG 666_ PQQTV 671_ GEVGL 676_ PPPLP 681_ SSQKD 686_ YLSNK 691_ PFKSH 696_ KSCSP 701_ SYKLL 706_ NTAVP 711_ REMKS 716_ NTSDP 721_ EIKVL 726_ EETKG 731_ PAPDP 736_ SAQDE 741_ LGRTL 746_ DGIGE 751_ PPEHC 756_ PETEA 761_ VSALS 766_ KVISN 771_ KCDGV 776_ CNFPE 781_ SSQNS 786_ PTGTP 791_ QQAQP 796_ DSMLG 801_ VPSKC 806_ VLDHS 811_ LSTVC 816_ NPPSA 821_ ACQTP 826_ LDPST 831_ DFLNQ 836_ DPSGS 841_ VASIS 846_ HQEQL 851_ SSVPD 856_ LTHGE 861_ EDIGK 866_ RGNNR 871_ NGQLL 876_ ENPRF 881_ GKMPL 886_ ELVRK 891_ PISQS 896_ QISEF 901_ SFLGS 906_ NWDSF 911_ QGMVT 916_ SFPSG 921_ EATPR 926_ RLLSY 931_ GCCSK 936_ RPNSK 941_ QMRAT 946_ GPCFG 951_ GQWAQ 956_ REGVK 961_ SPVCS 966_ SHSNG 971_ HCTGP 976_ GGKNQ 981_ MWLSS 986_ HPKQV 991_ SSTKP 996_ VPLNC 1001_ PSPVP 1006_ PLYLD 1011_ DDGLP 1016_ FPTDV 1021_ IQHRL 1026_ RQIEA 1031_ GYKQE 1036_ VEQLR 1041_ RQVRE 1046_ LQMRL 1051_ DIRHC 1056_ CAPPA 1061_ EPPMD 1066_ YEDDF 1071_ TCLKE 1076_ SDGSD 1081_ TEDFG 1086_ SDHSE 1091_ DCLSE 1096_ ASWEP 1101_ VDKKE 1106_ TEVTR 1111_ WVPDH 1116_ MASHC 1121_ YNCDC 1126_ EFWLA 1131_ KRRHH 1136_ CRNCG 1141_ NVFCA 1146_ GCCHL 1151_ KLPIP 1156_ DQQLY 1161_ DPVLV 1166_ CNSCY 1171_ EHIQV 1176_ SRARE 1181_ LMSQQ 1186_LKKPI
1: Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:11302699, PubMed:16787938, PubMed:20736309, PubMed:27625994, PubMed:29962048, PubMed:30944173). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic, in a subset of endosomal membranes to negatively regulate both endocytic recycling and trafficking and/or maturation of endosomes toward lysosomes (PubMed:16787938, PubMed:20736309, PubMed:29962048). Through phosphatidylinositol 3-phosphate turnover in phagosome membranes regulates phagocytosis and phagosome maturation (PubMed:31543504). By decreasing phosphatidylinositol 3-monophosphate (PI3P) levels in immune cells it can also regulate the innate immune response (PubMed:30944173). Beside its lipid phosphatase activity, can also function as a molecular adapter to regulate midbody abscission during mitotic cytokinesis (PubMed:25659891). Can also negatively regulate TGF-beta and BMP signaling through Smad proteins dephosphorylation and retention in endosomes (PubMed:20061380, PubMed:23150675)