Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Dopamine receptor-interacting protein 5) (Repressor/activator protein 1 homolog) (RAP1 homolog) (hRap1)
1_MAEAM 6_ DLGKD 11_ PNGPT 16_ HSSTL 21_ FVRDD 26_ GSSMS 31_ FYVRP 36_ SPAKR 41_ RLSTL 46_ ILHGG 51_ GTVCR 56_ VQEPG 61_ AVLLA 66_ QPGEA 71_ LAEAS 76_ GDFIS 81_ TQYIL 86_ DCVER 91_ NERLE 96_ LEAYR 101_ LGPAS 106_ AADTG 111_ SEAKP 116_ GALAE 121_ GAAEP 126_ EPQRH 131_ AGRIA 136_ FTDAD 141_ DVAIL 146_ TYVKE 151_ NARSP 156_ SSVTG 161_ NALWK 166_ AMEKS 171_ SLTQH 176_ SWQSL 181_ KDRYL 186_ KHLRG 191_ QEHKY 196_ LLGDA 201_ PVSPS 206_ SQKLK 211_ RKAEE 216_ DPEAA 221_ DSGEP 226_ QNKRT 231_ PDLPE 236_ EEYVK 241_ EEIQE 246_ NEEAV 251_ KKMLV 256_ EATRE 261_ FEEVV 266_ VDESP 271_ PDFEI 276_ HITMC 281_ DDDPP 286_ TPEED 291_ SETQP 296_ DEEEE 301_ EEEEK 306_ VSQPE 311_ VGAAI 316_ KIIRQ 321_ LMEKF 326_ NLDLS 331_ TVTQA 336_ FLKNS 341_ GELEA 346_ TSAFL 351_ ASGQR 356_ ADGYP 361_ IWSRQ 366_ DDIDL 371_ QKDDE 376_ DTREA 381_ LVKKF 386_ GAQNV 391_ARRIE
1: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes