Solute carrier organic anion transporter family member 1C1 (Organic anion transporter F) (OATP-F) (Organic anion transporter polypeptide-related protein 5) (OAT-RP-5) (OATPRP5) (Organic anion-transporting polypeptide 14) (OATP-14) (Solute carrier family 21 member 14) (Thyroxine transporter)
1_MDTSS 6_ KENIQ 11_ LFCKT 16_ SVQPV 21_ GRPSF 26_ KTEYP 31_ SSEEK 36_ QPCCG 41_ ELKVF 46_ LCALS 51_ FVYFA 56_ KALAE 61_ GYLKS 66_ TITQI 71_ ERRFD 76_ IPSSL 81_ VGVID 86_ GSFEI 91_ GNLLV 96_ ITFVS 101_ YFGAK 106_ LHRPK 111_ IIGAG 116_ CVIMG 121_ VGTLL 126_ IAMPQ 131_ FFMEQ 136_ YKYER 141_ YSPSS 146_ NSTLS 151_ ISPCL 156_ LESSS 161_ QLPVS 166_ VMEKS 171_ KSKIS 176_ NECEV 181_ DTSSS 186_ MWIYV 191_ FLGNL 196_ LRGIG 201_ ETPIQ 206_ PLGIA 211_ YLDDF 216_ ASEDN 221_ AAFYI 226_ GCVQT 231_ VAIIG 236_ PIFGF 241_ LLGSL 246_ CAKLY 251_ VDIGF 256_ VNLDH 261_ ITITP 266_ KDPQW 271_ VGAWW 276_ LGYLI 281_ AGIIS 286_ LLAAV 291_ PFWYL 296_ PKSLP 301_ RSQSR 306_ EDSNS 311_ SSEKS 316_ KFIID 321_ DHTDY 326_ QTPQG 331_ ENAKI 336_ MEMAR 341_ DFLPS 346_ LKNLF 351_ GNPVY 356_ FLYLC 361_ TSTVQ 366_ FNSLF 371_ GMVTY 376_ KPKYI 381_ EQQYG 386_ QSSSR 391_ ANFVI 396_ GLINI 401_ PAVAL 406_ GIFSG 411_ GIVMK 416_ KFRIS 421_ VCGAA 426_ KLYLG 431_ SSVFG 436_ YLLFL 441_ SLFAL 446_ GCENS 451_ DVAGL 456_ TVSYQ 461_ GTKPV 466_ SYHER 471_ ALFSD 476_ CNSRC 481_ KCSET 486_ KWEPM 491_ CGENG 496_ ITYVS 501_ ACLAG 506_ CQTSN 511_ RSGKN 516_ IIFYN 521_ CTCVG 526_ IAASK 531_ SGNSS 536_ GIVGR 541_ CQKDN 546_ GCPQM 551_ FLYFL 556_ VISVI 561_ TSYTL 566_ SLGGI 571_ PGYIL 576_ LLRCI 581_ KPQLK 586_ SFALG 591_ IYTLA 596_ IRVLA 601_ GIPAP 606_ VYFGV 611_ LIDTS 616_ CLKWG 621_ FKRCG 626_ SRGSC 631_ RLYDS 636_ NVFRH 641_ IYLGL 646_ TVILG 651_ TVSIL 656_ LSIAV 661_ LFILK 666_ KNYVS 671_ KHRSF 676_ ITKRE 681_ RTMVS 686_ TRFQK 691_ ENYTT 696_ SDHLL 701_ QPNYW 706_PGKET
1: Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones L-thyroxine (T4), L-thyroxine sulfate (T4S), and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) at the plasma membrane (PubMed:12351693, PubMed:18566113, PubMed:19129463). Regulates T4 levels in different brain regions by transporting T4, and also by serving as an export pump for T4S, which is a source of T4 after hydrolysis by local sulfatases (PubMed:18566113). Increases the access of these substrates to the intracellular sites where they are metabolized by the deiodinases (PubMed:18566113). Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)), estrone-3-sulfate (E1S) and sulfobromophthalein (BSP) are transported with much lower efficiency (PubMed:12351693, PubMed:19129463). Transports T4 and E1S in a pH-insensitive manner (PubMed:19129463). Facilitates the transport of thyroid hormones across the blood-brain barrier and into glia and neuronal cells in the brain (PubMed:30296914)