Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1)
1_MAELQ 6_ MLLEE 11_ EIPGG 16_ RRALF 21_ DSYTN 26_ LERVA 31_ DYCEN 36_ NYIQS 41_ ADKQR 46_ ALEET 51_ KAYTT 56_ QSLAS 61_ VAYLI 66_ NTLAN 71_ NVLQM 76_ LDIQA 81_ SQLRR 86_ MESSI 91_ NHISQ 96_ TVDIH 101_ KEKVA 106_ RREIG 111_ ILTTN 116_ KNTSR 121_ THKII 126_ APANL 131_ ERPVR 136_ YIRKP 141_ IDYTI 146_ LDDIG 151_ HGVKW 156_ LLRFK 161_ VSTQN 166_ MKMGG 171_ LPRTT 176_ PPTQK 181_ PPSPP 186_ MSGKG 191_ TLGRH 196_ SPYRT 201_ LEPVR 206_ PPVVP 211_ NDYVP 216_ SPTRN 221_ MAPSQ 226_ QSPVR 231_ TASVN 236_ QRNRT 241_ YSSSG 246_ SSGGS 251_ HPSSR 256_ SSSRE 261_ NSGSG 266_ SVGVP 271_ IAVPT 276_ PSPPS 281_ VFPAP 286_ AGSAG 291_ TPPLP 296_ ATSAS 301_ APAPL 306_ VPATV 311_ PSSTA 316_ PNAAA 321_ GGAPN 326_ LADGF 331_ TSPTP 336_ PVVSS 341_ TPPTG 346_ HPVQF 351_ YSMNR 356_ PASRH 361_ TPPTI 366_ GGSLP 371_ YRRPP 376_ SITSQ 381_ TSLQN 386_ QMNGG 391_ PFYSQ 396_ NPVSD 401_ TPPPP 406_ PPVEE 411_ PVFDE 416_ SPPPP 421_ PPPED 426_ YEEEE 431_ AAVVE 436_ YSDPY 441_ AEEDP 446_ PWAPR 451_ SYLEK 456_ VVAIY 461_ DYTKD 466_ KEDEL 471_ SFQEG 476_ AIIYV 481_ IKKND 486_ DGWYE 491_ GVMNG 496_ VTGLF 501_ PGNYV 506_ESIMH
1: Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692)