Dapper homolog 1 (hDPR1) (Dapper antagonist of catenin 1) (Hepatocellular carcinoma novel gene 3 protein)
1_MKPSP 6_ AGTAK 11_ ELEPP 16_ APARG 21_ EQRTA 26_ EPEGR 31_ WREKG 36_ EADTE 41_ RQRTR 46_ ERQEA 51_ TLAGL 56_ AELEY 61_ LRQRQ 66_ ELLVR 71_ GALRG 76_ AGGAG 81_ AAAPR 86_ AGELL 91_ GEAAQ 96_ RSRLE 101_ EKFLE 106_ ENILL 111_ LRKQL 116_ NCLRR 121_ RDAGL 126_ LNQLQ 131_ ELDKQ 136_ ISDLR 141_ LDVEK 146_ TSEEH 151_ LETDS 156_ RPSSG 161_ FYELS 166_ DGASG 171_ SLSNS 176_ SNSVF 181_ SECLS 186_ SCHSS 191_ TCFCS 196_ PLEAT 201_ LSLSD 206_ GCPKS 211_ ADLIG 216_ LLEYK 221_ EGHCE 226_ DQASG 231_ AVCRS 236_ LSTPQ 241_ FNSLD 246_ VIADV 251_ NPKYQ 256_ CDLVS 261_ KNGND 266_ VYRYP 271_ SPLHA 276_ VAVQS 281_ PMFLL 286_ CLTGN 291_ PLREE 296_ DRLGN 301_ HASDI 306_ CGGSE 311_ LDAVK 316_ TDSSL 321_ PSPSS 326_ LWSAS 331_ HPSSS 336_ KKMDG 341_ YILSL 346_ VQKKT 351_ HPVRT 356_ NKPRT 361_ SVNAD 366_ PTKGL 371_ LRNGS 376_ VCVRA 381_ PGGVS 386_ QGNSV 391_ NLKNS 396_ KQACL 401_ PSGGI 406_ PSLNN 411_ GTFSP 416_ PKQWS 421_ KESKA 426_ EQAES 431_ KRVPL 436_ PEGCP 441_ SGAAS 446_ DLQSK 451_ HLPKT 456_ AKPAS 461_ QEHAR 466_ CSAIG 471_ TGESP 476_ KESAQ 481_ LSGAS 486_ PKESP 491_ SRGPA 496_ PPQEN 501_ KVVQP 506_ LKKMS 511_ QKNSL 516_ QGVPP 521_ ATPPL 526_ LSTAF 531_ PVEER 536_ PALDF 541_ KSEGS 546_ SQSLE 551_ EAHLV 556_ KAQFI 561_ PGQQP 566_ SVRLH 571_ RGHRN 576_ MGVVK 581_ NSSLK 586_ HRGPA 591_ LQGLE 596_ NGLPT 601_ VREKT 606_ RAGSK 611_ KCRFP 616_ DDLDT 621_ NKKLK 626_ KASSK 631_ GRKSG 636_ GGPEA 641_ GVPGR 646_ PAGGG 651_ HRAGS 656_ RAHGH 661_ GREAV 666_ VAKPK 671_ HKRTD 676_ YRRWK 681_ SSAEI 686_ SYEEA 691_ LRRAR 696_ RGRRE 701_ NVGLY 706_ PAPVP 711_ LPYAS 716_ PYAYV 721_ ASDSE 726_ YSAEC 731_ ESLFH 736_ STVVD 741_ TSEDE 746_ QSNYT 751_ TNCFG 756_ DSESS 761_ VSEGE 766_ FVGES 771_ TTTSD 776_ SEESG 781_ GLIWS 786_ QFVQT 791_ LPIQT 796_ VTAPD 801_ LHNHP 806_ AKTFV 811_ KIKAS 816_ HNLKK 821_ KILRF 826_ RSGSL 831_KLMTT
1: Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity). The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines