Palmitoyltransferase ZDHHC3 (EC 2.3.1.225) (Acyltransferase ZDHHC3) (EC 2.3.1.-) (Protein DHHC1) (Zinc finger DHHC domain-containing protein 3) (DHHC-3)
1_MMLIP 6_ THHFR 11_ NIERK 16_ PEYLQ 21_ PEKCV 26_ PPPYP 31_ GPVGT 36_ MWFIR 41_ DGCGI 46_ ACAIV 51_ TWFLV 56_ LYAEF 61_ VVLFV 66_ MLIPS 71_ RDYVY 76_ SIING 81_ IVFNL 86_ LAFLA 91_ LASHC 96_ RAMLT 101_ DPGAV 106_ PKGNA 111_ TKEFI 116_ ESLQL 121_ KPGQV 126_ VYKCP 131_ KCCSI 136_ KPDRA 141_ HHCSV 146_ CKRCI 151_ RKMDH 156_ HCPWV 161_ NNCVG 166_ ENNQK 171_ YFVLF 176_ TMYIA 181_ LISLH 186_ ALIMV 191_ GFHFL 196_ HCFEE 201_ DWTKC 206_ SSFSP 211_ PTTVI 216_ LLILL 221_ CFEGL 226_ LFLIF 231_ TSVMF 236_ GTQVH 241_ SICTD 246_ ETGIE 251_ QLKKE 256_ ERRWA 261_ KKTKW 266_ MNMKA 271_ VFGHP 276_ FSLGW 281_ ASPFA 286_ TPDQG 291_KADPY
1: Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:19001095, PubMed:21926431, PubMed:22240897, PubMed:22314500, PubMed:23034182). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Plays an important role in G protein-coupled receptor signaling pathways involving GNAQ and potentially other heterotrimeric G proteins by regulating their dynamic association with the plasma membrane (PubMed:19001095). Palmitoylates ITGA6 and ITGB4, thereby regulating the alpha-6/beta-4 integrin localization, expression and function in cell adhesion to laminin (PubMed:22314500). Plays a role in the TRAIL-activated apoptotic signaling pathway most probably through the palmitoylation and localization to the plasma membrane of TNFRSF10A (PubMed:22240897). In the brain, by palmitoylating the gamma subunit GABRG2 of GABA(A) receptors and regulating their postsynaptic accumulation, plays a role in synaptic GABAergic inhibitory function and GABAergic innervation (By similarity). Palmitoylates the neuronal protein GAP43 which is also involved in the formation of GABAergic synapses (By similarity). Palmitoylates NCDN thereby regulating its association with endosome membranes (By similarity). Probably palmitoylates PRCD and is involved in its proper localization within the photoreceptor (By similarity). Could mediate the palmitoylation of NCAM1 and regulate neurite outgrowth (By similarity). Could palmitoylate DNAJC5 and regulate its localization to Golgi membranes (By similarity). Also constitutively palmitoylates DLG4 (By similarity). May also palmitoylate SNAP25 (By similarity). Could palmitoylate the glutamate receptors GRIA1 and GRIA2 but this has not been confirmed in vivo (By similarity). Could also palmitoylate the D(2) dopamine receptor DRD2 (PubMed:26535572). May also palmitoylate LAMTOR1, promoting its localization to lysosomal membranes (PubMed:35893977). Palmitoylates the Toll-like receptor 9/TLR9 in the Golgi and thereby regulates TLR9 trafficking to endosomes (PubMed:38169466). May palmitoylate CALHM1 and CALHM3 subunits of gustatory voltage-gated ion channels and modulate channel gating and kinetics
2: May also function as a calcium transporter