TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2)
1_MAQGS 6_ HQIDF 11_ QVLHD 16_ LRQKF 21_ PEVPE 26_ VVVSR 31_ CMLQN 36_ NNNLD 41_ ACCAV 46_ LSQES 51_ TRYLY 56_ GEGDL 61_ NFSDD 66_ SGISG 71_ LRNHM 76_ TSLNL 81_ DLQSQ 86_ NIYHH 91_ GREGS 96_ RMNGS 101_ RTLTH 106_ SISDG 111_ QLQGG 116_ QSNSE 121_ LFQQE 126_ PQTAP 131_ AQVPQ 136_ GFNVF 141_ GMSSS 146_ SGASN 151_ SAPHL 156_ GFHLG 161_ SKGTS 166_ SLSQQ 171_ TPRFN 176_ PIMVT 181_ LAPNI 186_ QTGRN 191_ TPTSL 196_ HIHGV 201_ PPPVL 206_ NSPQG 211_ NSIYI 216_ RPYIT 221_ TPGGT 226_ TRQTQ 231_ QHSGW 236_ VSQFN 241_ PMNPQ 246_ QVYQP 251_ SQPGP 256_ WTTCP 261_ ASNPL 266_ SHTSS 271_ QQPNQ 276_ QGHQT 281_ SHVYM 286_ PISSP 291_ TTSQP 296_ PTIHS 301_ SGSSQ 306_ SSAHS 311_ QYNIQ 316_ NISTG 321_ PRKNQ 326_ IEIKL 331_ EPPQR 336_ NNSSK 341_ LRSSG 346_ PRTSS 351_ TSSSV 356_ NSQTL 361_ NRNQP 366_ TVYIA 371_ ASPPN 376_ TDELM 381_ SRSQP 386_ KVYIS 391_ ANAAT 396_ GDEQV 401_ MRNQP 406_ TLFIS 411_ TNSGA 416_ SAASR 421_ NMSGQ 426_ VSMGP 431_ AFIHH 436_ HPPKS 441_ RAIGN 446_ NSATS 451_ PRVVV 456_ TQPNT 461_ KYTFK 466_ ITVSP 471_ NKPPA 476_ VSPGV 481_ VSPTF 486_ ELTNL 491_ LNHPD 496_ HYVET 501_ ENIQH 506_ LTDPT 511_ LAHVD 516_ RISET 521_ RKLSM 526_ GSDDA 531_ AYTQA 536_ LLVHQ 541_ KARME 546_ RLQRE 551_ LEIQK 556_ KKLDK 561_ LKSEV 566_ NEMEN 571_ NLTRR 576_ RLKRS 581_ NSISQ 586_ IPSLE 591_ EMQQL 596_ RSCNR 601_ QLQID 606_ IDCLT 611_ KEIDL 616_ FQARG 621_ PHFNP 626_ SAIHN 631_ FYDNI 636_ GFVGP 641_ VPPKP 646_ KDQRS 651_ IIKTP 656_ KTQDT 661_ EDDEG 666_ AQWNC 671_ TACTF 676_ LNHPA 681_ LIRCE 686_QCEMP
1: Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:27746020, PubMed:33184450, PubMed:36681779). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (PubMed:10882101, PubMed:11460167, PubMed:15327770, PubMed:22158122, PubMed:27746020). The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:15327770, PubMed:18079694, PubMed:22158122). Also recognizes and binds Lys-63'-linked polyubiquitin chains of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (PubMed:27746020). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (PubMed:20493459)