Toll-like receptor 7
1_MVFPM 6_ WTLKR 11_ QILIL 16_ FNIIL 21_ ISKLL 26_ GARWF 31_ PKTLP 36_ CDVTL 41_ DVPKN 46_ HVIVD 51_ CTDKH 56_ LTEIP 61_ GGIPT 66_ NTTNL 71_ TLTIN 76_ HIPDI 81_ SPASF 86_ HRLDH 91_ LVEID 96_ FRCNC 101_ VPIPL 106_ GSKNN 111_ MCIKR 116_ LQIKP 121_ RSFSG 126_ LTYLK 131_ SLYLD 136_ GNQLL 141_ EIPQG 146_ LPPSL 151_ QLLSL 156_ EANNI 161_ FSIRK 166_ ENLTE 171_ LANIE 176_ ILYLG 181_ QNCYY 186_ RNPCY 191_ VSYSI 196_ EKDAF 201_ LNLTK 206_ LKVLS 211_ LKDNN 216_ VTAVP 221_ TVLPS 226_ TLTEL 231_ YLYNN 236_ MIAKI 241_ QEDDF 246_ NNLNQ 251_ LQILD 256_ LSGNC 261_ PRCYN 266_ APFPC 271_ APCKN 276_ NSPLQ 281_ IPVNA 286_ FDALT 291_ ELKVL 296_ RLHSN 301_ SLQHV 306_ PPRWF 311_ KNINK 316_ LQELD 321_ LSQNF 326_ LAKEI 331_ GDAKF 336_ LHFLP 341_ SLIQL 346_ DLSFN 351_ FELQV 356_ YRASM 361_ NLSQA 366_ FSSLK 371_ SLKIL 376_ RIRGY 381_ VFKEL 386_ KSFNL 391_ SPLHN 396_ LQNLE 401_ VLDLG 406_ TNFIK 411_ IANLS 416_ MFKQF 421_ KRLKV 426_ IDLSV 431_ NKISP 436_ SGDSS 441_ EVGFC 446_ SNART 451_ SVESY 456_ EPQVL 461_ EQLHY 466_ FRYDK 471_ YARSC 476_ RFKNK 481_ EASFM 486_ SVNES 491_ CYKYG 496_ QTLDL 501_ SKNSI 506_ FFVKS 511_ SDFQH 516_ LSFLK 521_ CLNLS 526_ GNLIS 531_ QTLNG 536_ SEFQP 541_ LAELR 546_ YLDFS 551_ NNRLD 556_ LLHST 561_ AFEEL 566_ HKLEV 571_ LDISS 576_ NSHYF 581_ QSEGI 586_ THMLN 591_ FTKNL 596_ KVLQK 601_ LMMND 606_ NDISS 611_ STSRT 616_ MESES 621_ LRTLE 626_ FRGNH 631_ LDVLW 636_ REGDN 641_ RYLQL 646_ FKNLL 651_ KLEEL 656_ DISKN 661_ SLSFL 666_ PSGVF 671_ DGMPP 676_ NLKNL 681_ SLAKN 686_ GLKSF 691_ SWKKL 696_ QCLKN 701_ LETLD 706_ LSHNQ 711_ LTTVP 716_ ERLSN 721_ CSRSL 726_ KNLIL 731_ KNNQI 736_ RSLTK 741_ YFLQD 746_ AFQLR 751_ YLDLS 756_ SNKIQ 761_ MIQKT 766_ SFPEN 771_ VLNNL 776_ KMLLL 781_ HHNRF 786_ LCTCD 791_ AVWFV 796_ WWVNH 801_ TEVTI 806_ PYLAT 811_ DVTCV 816_ GPGAH 821_ KGQSV 826_ ISLDL 831_ YTCEL 836_ DLTNL 841_ ILFSL 846_ SISVS 851_ LFLMV 856_ MMTAS 861_ HLYFW 866_ DVWYI 871_ YHFCK 876_ AKIKG 881_ YQRLI 886_ SPDCC 891_ YDAFI 896_ VYDTK 901_ DPAVT 906_ EWVLA 911_ ELVAK 916_ LEDPR 921_ EKHFN 926_ LCLEE 931_ RDWLP 936_ GQPVL 941_ ENLSQ 946_ SIQLS 951_ KKTVF 956_ VMTDK 961_ YAKTE 966_ NFKIA 971_ FYLSH 976_ QRLMD 981_ EKVDV 986_ IILIF 991_ LEKPF 996_ QKSKF 1001_ LQLRK 1006_ RLCGS 1011_ SVLEW 1016_ PTNPQ 1021_ AHPYF 1026_ WQCLK 1031_ NALAT 1036_ DNHVA 1041_YSQVF
1: Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:14976261, PubMed:32433612). Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed:12738885, PubMed:27742543, PubMed:31608988, PubMed:32706371, PubMed:35477763). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:27742543). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively (PubMed:27742543, PubMed:32706371). In plasmacytoid dendritic cells, RNASET2 endonuclease cooperates with PLD3 or PLD4 5'->3' exonucleases to process RNA and release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP) and cytidine-rich RNA fragments that occupy TLR7 ligand-binding pockets and trigger a signaling-competent state