Elongation of very long chain fatty acids protein 5 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL5) (ELOVL fatty acid elongase 5) (ELOVL FA elongase 5) (Fatty acid elongase 1) (hELO1) (Very long chain 3-ketoacyl-CoA synthase 5) (Very long chain 3-oxoacyl-CoA synthase 5)
1_MEHFD 6_ ASLST 11_ YFKAL 16_ LGPRD 21_ TRVKG 26_ WFLLD 31_ NYIPT 36_ FICSV 41_ IYLLI 46_ VWLGP 51_ KYMRN 56_ KQPFS 61_ CRGIL 66_ VVYNL 71_ GLTLL 76_ SLYMF 81_ CELVT 86_ GVWEG 91_ KYNFF 96_ CQGTR 101_ TAGES 106_ DMKII 111_ RVLWW 116_ YYFSK 121_ LIEFM 126_ DTFFF 131_ ILRKN 136_ NHQIT 141_ VLHVY 146_ HHASM 151_ LNIWW 156_ FVMNW 161_ VPCGH 166_ SYFGA 171_ TLNSF 176_ IHVLM 181_ YSYYG 186_ LSSVP 191_ SMRPY 196_ LWWKK 201_ YITQG 206_ QLLQF 211_ VLTII 216_ QTSCG 221_ VIWPC 226_ TFPLG 231_ WLYFQ 236_ IGYMI 241_ SLIAL 246_ FTNFY 251_ IQTYN 256_ KKGAS 261_ RRKDH 266_ LKDHQ 271_ NGSMA 276_ AVNGH 281_ TNSFS 286_ PLENN 291_VKPRK
1: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity) (PubMed:10970790, PubMed:20937905). In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid (By similarity)