2-Hydroxyacid oxidase 2 (HAOX2) (EC 1.1.3.15) ((S)-2-hydroxy-acid oxidase, peroxisomal) (Cell growth-inhibiting gene 16 protein) (Long chain alpha-hydroxy acid oxidase) (Long-chain L-2-hydroxy acid oxidase)
1_MSLVC 6_ LTDFQ 11_ AHARE 16_ QLSKS 21_ TRDFI 26_ EGGAD 31_ DSITR 36_ DDNIA 41_ AFKRI 46_ RLRPR 51_ YLRDV 56_ SEVDT 61_ RTTIQ 66_ GEEIS 71_ APICI 76_ APTGF 81_ HCLVW 86_ PDGEM 91_ STARA 96_ AQAAG 101_ ICYIT 106_ STFAS 111_ CSLED 116_ IVIAA 121_ PEGLR 126_ WFQLY 131_ VHPDL 136_ QLNKQ 141_ LIQRV 146_ ESLGF 151_ KALVI 156_ TLDTP 161_ VCGNR 166_ RHDIR 171_ NQLRR 176_ NLTLT 181_ DLQSP 186_ KKGNA 191_ IPYFQ 196_ MTPIS 201_ TSLCW 206_ NDLSW 211_ FQSIT 216_ RLPII 221_ LKGIL 226_ TKEDA 231_ ELAVK 236_ HNVQG 241_ IIVSN 246_ HGGRQ 251_ LDEVL 256_ ASIDA 261_ LTEVV 266_ AAVKG 271_ KIEVY 276_ LDGGV 281_ RTGND 286_ VLKAL 291_ ALGAK 296_ CIFLG 301_ RPILW 306_ GLACK 311_ GEHGV 316_ KEVLN 321_ ILTNE 326_ FHTSM 331_ ALTGC 336_ RSVAE 341_ INRNL 346_VQFSR
1: Oxidase that catalyzes the oxidation of medium and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, to the correspondong 2-oxoacids (PubMed:10777549). Its role in the oxidation of 2-hydroxy fatty acids may contribute to the general pathway of fatty acid alpha-oxidation (Probable). Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2. Is not active on glycolate, glyoxylate, L-lactate and 2-hydroxybutanoate (PubMed:10777549)