NF-kappa-B inhibitor-interacting Ras-like protein 2 (I-kappa-B-interacting Ras-like protein 2) (Kappa B-Ras protein 2) (KappaB-Ras2)
1_MGKSC 6_ KVVVC 11_ GQASV 16_ GKTSI 21_ LEQLL 26_ YGNHV 31_ VGSEM 36_ IETQE 41_ DIYVG 46_ SIETD 51_ RGVRE 56_ QVRFY 61_ DTRGL 66_ RDGAE 71_ LPRHC 76_ FSCTD 81_ GYVLV 86_ YSTDS 91_ RESFQ 96_ RVELL 101_ KKEID 106_ KSKDK 111_ KEVTI 116_ VVLGN 121_ KCDLQ 126_ EQRRV 131_ DPDVA 136_ QHWAK 141_ SEKVK 146_ LWEVS 151_ VADRR 156_ SLLEP 161_ FVYLA 166_ SKMTQ 171_ PQSKS 176_ AFPLS 181_ RKNKG 186_SGSLD
1: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity)