NF-kappa-B inhibitor-interacting Ras-like protein 1 (I-kappa-B-interacting Ras-like protein 1) (Kappa B-Ras protein 1) (KappaB-Ras1)
1_MGKGC 6_ KVVVC 11_ GLLSV 16_ GKTAI 21_ LEQLL 26_ YGNHT 31_ IGMED 36_ CETME 41_ DVYMA 46_ SVETD 51_ RGVKE 56_ QLHLY 61_ DTRGL 66_ QEGVE 71_ LPKHY 76_ FSFAD 81_ GFVLV 86_ YSVNN 91_ LESFQ 96_ RVELL 101_ KKEID 106_ KFKDK 111_ KEVAI 116_ VVLGN 121_ KIDLS 126_ EQRQV 131_ DAEVA 136_ QQWAK 141_ SEKVR 146_ LWEVT 151_ VTDRK 156_ TLIEP 161_ FTLLA 166_ SKLSQ 171_ PQSKS 176_ SFPLP 181_ GRKNK 186_GNSNS
1: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB