Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)
1_MPNSE 6_ RHGGK 11_ KDGSG 16_ GASGT 21_ LQPSS 26_ GGGSS 31_ NSRER 36_ HRLVS 41_ KHKRH 46_ KSKHS 51_ KDMGL 56_ VTPEA 61_ ASLGT 66_ VIKPL 71_ VEYDD 76_ ISSDS 81_ DTFSD 86_ DMAFK 91_ LDRRE 96_ NDERR 101_ GSDRS 106_ DRLHK 111_ HRHHQ 116_ HRRSR 121_ DLLKA 126_ KQTEK 131_ EKSQE 136_ VSSKS 141_ GSMKD 146_ RISGS 151_ SKRSN 156_ EETDD 161_ YGKAQ 166_ VAKSS 171_ SKESR 176_ SSKLH 181_ KEKTR 186_ KEREL 191_ KSGHK 196_ DRSKS 201_ HRKRE 206_ TPKSY 211_ KTVDS 216_ PKRRS 221_ RSPHR 226_ KWSDS 231_ SKQDD 236_ SPSGA 241_ SYGQD 246_ YDLSP 251_ SRSHT 256_ SSNYD 261_ SYKKS 266_ PGSTS 271_ RRQSV 276_ SPPYK 281_ EPSAY 286_ QSSTR 291_ SPSPY 296_ SRRQR 301_ SVSPY 306_ SRRRS 311_ SSYER 316_ SGSYS 321_ GRSPS 326_ PYGRR 331_ RSSSP 336_ FLSKR 341_ SLSRS 346_ PLPSR 351_ KSMKS 356_ RSRSP 361_ AYSRH 366_ SSSHS 371_ KKKRS 376_ SSRSR 381_ HSSIS 386_ PVRLP 391_ LNSSL 396_ GAELS 401_ RKKKE 406_ RAAAA 411_ AAAKM 416_ DGKES 421_ KGSPV 426_ FLPRK 431_ ENSSV 436_ EAKDS 441_ GLESK 446_ KLPRS 451_ VKLEK 456_ SAPDT 461_ ELVNV 466_ THLNT 471_ EVKNS 476_ SDTGK 481_ VKLDE 486_ NSEKH 491_ LVKDL 496_ KAQGT 501_ RDSKP 506_ IALKE 511_ EIVTP 516_ KETET 521_ SEKET 526_ PPPLP 531_ TIASP 536_ PPPLP 541_ TTTPP 546_ PQTPP 551_ LPPLP 556_ PIPAL 561_ PQQPP 566_ LPPSQ 571_ PAFSQ 576_ VPASS 581_ TSTLP 586_ PSTHS 591_ KTSAV 596_ SSQAN 601_ SQPPV 606_ QVSVK 611_ TQVSV 616_ TAAIP 621_ HLKTS 626_ TLPPL 631_ PLPPL 636_ LPGDD 641_ DMDSP 646_ KETLP 651_ SKPVK 656_ KEKEQ 661_ RTRHL 666_ LTDLP 671_ LPPEL 676_ PGGDL 681_ SPPDS 686_ PEPKA 691_ ITPPQ 696_ QPYKK 701_ RPKIC 706_ CPRYG 711_ ERRQT 716_ ESDWG 721_ KRCVD 726_ KFDII 731_ GIIGE 736_ GTYGQ 741_ VYKAK 746_ DKDTG 751_ ELVAL 756_ KKVRL 761_ DNEKE 766_ GFPIT 771_ AIREI 776_ KILRQ 781_ LIHRS 786_ VVNMK 791_ EIVTD 796_ KQDAL 801_ DFKKD 806_ KGAFY 811_ LVFEY 816_ MDHDL 821_ MGLLE 826_ SGLVH 831_ FSEDH 836_ IKSFM 841_ KQLME 846_ GLEYC 851_ HKKNF 856_ LHRDI 861_ KCSNI 866_ LLNNS 871_ GQIKL 876_ ADFGL 881_ ARLYN 886_ SEESR 891_ PYTNK 896_ VITLW 901_ YRPPE 906_ LLLGE 911_ ERYTP 916_ AIDVW 921_ SCGCI 926_ LGELF 931_ TKKPI 936_ FQANL 941_ ELAQL 946_ ELISR 951_ LCGSP 956_ CPAVW 961_ PDVIK 966_ LPYFN 971_ TMKPK 976_ KQYRR 981_ RLREE 986_ FSFIP 991_ SAALD 996_ LLDHM 1001_ LTLDP 1006_ SKRCT 1011_ AEQTL 1016_ QSDFL 1021_ KDVEL 1026_ SKMAP 1031_ PDLPH 1036_ WQDCH 1041_ ELWSK 1046_ KRRRQ 1051_ RQSGV 1056_ VVEEP 1061_ PPSKT 1066_ SRKET 1071_ TSGTS 1076_ TEPVK 1081_ NSSPA 1086_ PPQPA 1091_ PGKVE 1096_ SGAGD 1101_ AIGLA 1106_ DITQQ 1111_ LNQSE 1116_ LAVLL 1121_ NLLQS 1126_ QTDLS 1131_ IPQMA 1136_ QLLNI 1141_ HSNPE 1146_ MQQQL 1151_ EALNQ 1156_ SISAL 1161_ TEATS 1166_ QQQDS 1171_ ETMAP 1176_ EESLK 1181_ EAPSA 1186_ PVILP 1191_ SAEQT 1196_ TLEAS 1201_ STPAD 1206_ MQNIL 1211_ AVLLS 1216_ QLMKT 1221_ QEPAG 1226_ SLEEN 1231_ NSDKN 1236_ SGPQG 1241_ PRRTP 1246_ TMPQE 1251_ EAAAC 1256_ PPHIL 1261_ PPEKR 1266_ PPEPP 1271_ GPPPP 1276_ PPPPP 1281_ LVEGD 1286_ LSSAP 1291_ QELNP 1296_ AVTAA 1301_ LLQLL 1306_ SQPEA 1311_ EPPGH 1316_ LPHEH 1321_ QALRP 1326_ MEYST 1331_ RPRPN 1336_ RTYGN 1341_ TDGPE 1346_ TGFSA 1351_ IDTDE 1356_ RNSGP 1361_ ALTES 1366_ LVQTL 1371_ VKNRT 1376_ FSGSL 1381_ SHLGE 1386_ SSSYQ 1391_ GTGSV 1396_ QFPGD 1401_ QDLRF 1406_ ARVPL 1411_ ALHPV 1416_ VGQPF 1421_ LKAEG 1426_ SSNSV 1431_ VHAET 1436_ KLQNY 1441_ GELGP 1446_ GTTGA 1451_ SSSGA 1456_ GLHWG 1461_ GPTQS 1466_ SAYGK 1471_ LYRGP 1476_ TRVPP 1481_RGGRG
1: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors