Interleukin-20 (IL-20) (Cytokine Zcyto10)
1_MKASS 6_ LAFSL 11_ LSAAF 16_ YLLWT 21_ PSTGL 26_ KTLNL 31_ GSCVI 36_ ATNLQ 41_ EIRNG 46_ FSEIR 51_ GSVQA 56_ KDGNI 61_ DIRIL 66_ RRTES 71_ LQDTK 76_ PANRC 81_ CLLRH 86_ LLRLY 91_ LDRVF 96_ KNYQT 101_ PDHYT 106_ LRKIS 111_ SLANS 116_ FLTIK 121_ KDLRL 126_ CHAHM 131_ TCHCG 136_ EEAMK 141_ KYSQI 146_ LSHFE 151_ KLEPQ 156_ AAVVK 161_ ALGEL 166_ DILLQ 171_WMEET
1: Pro-inflammatory and angiogenic cytokine mainly secreted by monocytes and skin keratinocytes that plays crucial roles in immune responses, regulation of inflammatory responses, hemopoiesis, as well as epidermal cell and keratinocyte differentiation (PubMed:17277128, PubMed:34403503). Enhances tissue remodeling and wound-healing activities and restores the homeostasis of epithelial layers during infection and inflammatory responses to maintain tissue integrity (PubMed:17277128). Affects multiple actin-mediated functions in activated neutrophils leading to inhibition of phagocytosis, granule exocytosis, and migration (PubMed:28424238). Exert its effects via the type I IL-20 receptor complex consisting of IL20RA and IL20RB (PubMed:11706020). Alternatively, can mediate its activity through a second receptor complex called type II IL-20 receptor complex composed of IL22RA1 and IL20RB (PubMed:11564763). Acts as an arteriogenic and vascular remodeling factory by activating a range of signaling processes including phosphorylations of JAK2 and STAT5 as well as activation of the serine and threonine kinases AKT and ERK1/2 (By similarity). Alternatively, can activate STAT3 phosphorylation and transcriptional activity in a JAK2, ERK1/2 and p38 MAPK-dependent manner in keratinocytes (PubMed:23614738)